TNFβ Antibody (D-10): sc-48410
- TNFβ Antibody (D-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 35-205 of TNFβ of human origin
- recommended for detection of TNFβ of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TNFβ Antibody (D-10) for WB applications. These reagents are now offered in bundles with TNFβ Antibody (D-10) (see ordering information below).
TNFβ Antibody (D-10) is a mouse monoclonal IgG2a light chain antibody that detects tumor necrosis factor β (TNFβ) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TNFβ is a pleiotropic cytokine produced primarily by activated lymphocytes, including CD4(+) T helper type 1 cells, CD8(+) lymphocytes, and certain B lymphoblastoid cell lines, playing a crucial role in immune regulation and inflammation. Notably, TNFβ interacts with TNF receptors 1 and 2 on target tumor cells, which is essential for mediating cytotoxic effects; specifically, the p55 receptor is responsible for triggering the cytotoxic response. This interaction allows TNFβ to modulate various immune and inflammatory functions while also possessing the ability to inhibit tumor growth, making TNFβ a significant player in both immune response and cancer therapy. Anti-TNFβ antibody (D-10) serves as an invaluable tool for researchers studying the complex roles of cytokines in health and disease, providing insights into therapeutic strategies targeting TNF signaling pathways.
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TNFβ Antibody (D-10) References:
- Tumor necrosis factor-alpha and TNF-beta inhibit clonogenicity of mobilized human hematopoietic progenitors. | Skobin, V., et al. 2000. J Interferon Cytokine Res. 20: 507-10. PMID: 10841079
- Tumor necrosis factor beta gene polymorphisms associated with urinary tract infections after renal transplantation. | Kimball, P. and Reid, F. 2002. Transplantation. 73: 1110-2. PMID: 11965041
- Interleukin-13 and tumor necrosis factor-beta differentially regulate the production of cytokines by cultured human endometrial stromal cells. | Nasu, K., et al. 2003. Fertil Steril. 79 Suppl 1: 821-7. PMID: 12620497
- Tumor necrosis factor-beta induces sleep, fever, and anorexia. | Kapás, L. and Krueger, JM. 1992. Am J Physiol. 263: R703-7. PMID: 1415661
- Potential role of lymphotoxin-alpha (tumor necrosis factor-beta) in the development of schizophrenia. | Pae, CU. 2007. Med Hypotheses. 68: 1359-62. PMID: 17140746
- Antitumor effect of natural human tumor necrosis factor-beta against Lewis lung carcinoma in mice and its synergistic potentiation by interferon. | Nishiyama, Y., et al. 1989. Acta Med Okayama. 43: 17-27. PMID: 2470233
- Independent and additive interaction between tumor necrosis factor β +252 polymorphisms and chronic hepatitis B and C virus infection on risk and prognosis of hepatocellular carcinoma: a case-control study. | Jeng, JE., et al. 2014. Asian Pac J Cancer Prev. 15: 10209-15. PMID: 25556449
- Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum. | Saxne, T., et al. 1988. Arthritis Rheum. 31: 1041-5. PMID: 3136775
- Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis. | de Kossodo, S., et al. 1994. Infect Immun. 62: 1414-20. PMID: 8132347
- Tumor necrosis factor beta gene polymorphism and early primary kidney allograft loss. | Mahoney, RJ., et al. 1996. Hum Immunol. 50: 148-50. PMID: 8891739
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNFβ Antibody (D-10) | sc-48410 | 200 µg/ml | $322.00 | |||
TNFβ Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-536833 | 200 µg Ab; 10 µg BP | $361.00 | |||
TNFβ Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-534000 | 200 µg Ab; 40 µg BP | $361.00 | |||
TNFβ Antibody (D-10): m-IgG2a BP-HRP Bundle | sc-547879 | 200 µg Ab; 10 µg BP | $361.00 |