TNF alpha Antibody (E-4): sc-133193

TNFα Antibody (E-4) is a mouse monoclonal IgG2a antibody that detects tumor necrosis factor α (TNFα) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TNFα is a critical cytokine involved in systemic inflammation and is produced by various immune cells, including lymphocytes, neutrophils, and macrophages. TNFα′s primary function is to regulate immune responses and inflammation, making TNFα essential for the body′s defense against infections and in the pathogenesis of autoimmune diseases. TNFα interacts with two main receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which mediate diverse biological effects, including cell proliferation, differentiation, and apoptosis. TNFα′s ability to induce apoptosis in tumor cells is particularly significant, as TNFα can enhance the immune system′s ability to target and eliminate cancerous cells. TNFα′s presence in the tumor microenvironment can influence the efficacy of various cancer therapies, highlighting TNFα′s importance in both immunology and oncology. Anti-TNFα antibody (E-4) is an invaluable tool for researchers studying the complex roles of this cytokine in health and disease.

The preferred TNF alpha antibody is TNF alpha Antibody (52B83): sc-52746.