TMTSP Antibody (H-11): sc-376994
- TMTSP Antibody (H-11) is a mouse monoclonal IgG1 κ TMTSP antibody provided at 200 µg/ml
- raised against amino acids 65-344 mapping within an N-terminal extracellular domain of TMTSP of human origin
- TMTSP Antibody (H-11) is recommended for detection of Thrombospondin type-1 domain-containing protein 1 precursor of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TMTSP Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMTSP Antibody (H-11) for WB and IHC(P) applications. These reagents are now offered in bundles with TMTSP Antibody (H-11) (see ordering information below).
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TMTSP Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TMTSP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TMTSP monoclonal antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMTSP, or transmembrane molecule with Thrombospondin module, is also known as THSD1 (Thrombospondin type-1 domain-containing protein 1) and consists of 852 amino acids, primarily expressed in endothelial and hematopoietic cells. TMTSP plays a crucial role in cell adhesion and migration, which are vital processes in tissue repair and immune response. TMTSP is known to interact with various extracellular matrix proteins and thrombospondins, highlighting its importance in cellular signaling and the regulation of angiogenesis. Additionally, TMTSP undergoes alternative splicing, resulting in three isoforms; isoforms 1 and 2 function as single-pass type I membrane proteins, while isoform 3 is secreted, further diversifying its functional roles in the cellular environment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMTSP Antibody (H-11) References:
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | Clark, HF., et al. 2003. Genome Res. 13: 2265-70. PMID: 12975309
- Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. | Orr, AW., et al. 2004. J Biol Chem. 279: 48983-92. PMID: 15371459
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. | Takayanagi, S., et al. 2006. Blood. 107: 4317-25. PMID: 16455951
- Immunolocalization of thrombospondin in the human and sand rat intervertebral disc. | Gruber, HE., et al. 2006. Spine (Phila Pa 1976). 31: 2556-61. PMID: 17047544
- Microarray analysis of radiation response genes in primary human fibroblasts. | Kis, E., et al. 2006. Int J Radiat Oncol Biol Phys. 66: 1506-14. PMID: 17069989
- The modular architecture of a new family of growth regulators related to connective tissue growth factor. | Bork, P. 1993. FEBS Lett. 327: 125-30. PMID: 7687569
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMTSP Antibody (H-11) | sc-376994 | 200 µg/ml | $316.00 | |||
TMTSP Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-529952 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMTSP Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-523143 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMTSP Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-543782 | 200 µg Ab; 20 µg BP | $354.00 | |||
TMTSP Antibody (H-11) AC | sc-376994 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMTSP Antibody (H-11) HRP | sc-376994 HRP | 200 µg/ml | $316.00 | |||
TMTSP Antibody (H-11) FITC | sc-376994 FITC | 200 µg/ml | $330.00 | |||
TMTSP Antibody (H-11) PE | sc-376994 PE | 200 µg/ml | $343.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 488 | sc-376994 AF488 | 200 µg/ml | $357.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 546 | sc-376994 AF546 | 200 µg/ml | $357.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 594 | sc-376994 AF594 | 200 µg/ml | $357.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 647 | sc-376994 AF647 | 200 µg/ml | $357.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 680 | sc-376994 AF680 | 200 µg/ml | $357.00 | |||
TMTSP Antibody (H-11) Alexa Fluor® 790 | sc-376994 AF790 | 200 µg/ml | $357.00 |