TMEM205 Antibody (G-1): sc-390447

TMEM205 Antibody (G-1) is a mouse monoclonal IgG2b antibody that detects TMEM205 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEM205 is a 189 amino acid transmembrane protein predominantly expressed in the liver, pancreas, and adrenal glands, playing a crucial role in cellular signaling and potentially influencing drug resistance in cancer therapy. Notably, TMEM205 has been implicated in the development of cisplatin resistance, as elevated levels of TMEM205 in conjunction with Rab 8 may hinder the efficacy of this potent platinum-based anti-neoplastic agent, which operates by forming DNA adducts that trigger apoptosis. Understanding the function of TMEM205 is vital, as TMEM205 may serve as a biomarker or therapeutic target in cancer chemotherapy, providing insights into overcoming resistance mechanisms. The TMEM205 gene is located on human chromosome 19, a region that encompasses approximately 63 million bases and contains over 1,400 genes, representing more than 2% of the human genome. With diverse applications and significant biological implications, anti-TMEM205 antibody (G-1) is an essential tool for researchers investigating the complexities of cancer treatment and cellular responses.

The preferred TMEM205 antibody is TMEM205 Antibody (B-5): sc-514568.