TMEM205 Antibody (B-5): sc-514568
- TMEM205 Antibody (B-5) is a mouse monoclonal IgG2a κ TMEM205 antibody provided at 200 µg/ml
- raised against amino acids 15-179 mapping within an internal region of TMEM205 of human origin
- TMEM205 Antibody (B-5) is recommended for detection of TMEM205 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMEM205 Antibody (B-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMEM205 Antibody (B-5) for WB applications. These reagents are now offered in bundles with TMEM205 Antibody (B-5) (see ordering information below).
QUICK LINKS
SEE ALSO...
TMEM205 Antibody (B-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects TMEM205 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEM205 monoclonal antibody (B-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEM205, a 189 amino acid transmembrane protein, plays a crucial role in cellular processes, particularly in cancer therapy, as TMEM205 has been implicated in developing resistance to cisplatin, a widely used platinum-based chemotherapeutic agent. Elevated levels of TMEM205, along with Rab 8, have been associated with reduced sensitivity to cisplatin, highlighting TMEM205′s potential as a biomarker for predicting treatment outcomes in cancer patients. TMEM205 is predominantly expressed in the liver, pancreas, and adrenal glands, which are vital organs involved in metabolism and hormone regulation, making TMEM205 study essential for understanding normal physiology and disease states. TMEM205 gene is located on human chromosome 19, which contains approximately 63 million bases and over 1,400 genes, representing more than 2% of the human genome. Anti-TMEM205 antibody (B-5) serves as an invaluable tool for researchers investigating drug resistance mechanisms and therapeutic potential in cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMEM205 Antibody (B-5) References:
- Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Siddik, ZH. 2003. Oncogene. 22: 7265-79. PMID: 14576837
- Role of transporter genes in cisplatin resistance. | Konkimalla, VB., et al. 2008. In Vivo. 22: 279-83. PMID: 18610736
- Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. | Shen, DW., et al. 2010. J Cell Physiol. 225: 822-8. PMID: 20589834
- RAB8 enhances TMEM205-mediated cisplatin resistance. | Shen, DW. and Gottesman, MM. 2012. Pharm Res. 29: 643-50. PMID: 21969054
- The association of transporter genes polymorphisms and lung cancer chemotherapy response. | Wang, Y., et al. 2014. PLoS One. 9: e91967. PMID: 24643204
- Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients. | Dorr, C., et al. 2015. PLoS One. 10: e0125045. PMID: 25946140
- A deficiency of the small GTPase rab8 inhibits membrane traffic in developing neurons. | Huber, LA., et al. 1995. Mol Cell Biol. 15: 918-24. PMID: 7823956
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEM205 Antibody (B-5) | sc-514568 | 200 µg/ml | $316.00 | |||
TMEM205 Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-531163 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEM205 Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-524773 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMEM205 Antibody (B-5): m-IgG2a BP-HRP Bundle | sc-547710 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEM205 Antibody (B-5) AC | sc-514568 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMEM205 Antibody (B-5) HRP | sc-514568 HRP | 200 µg/ml | $316.00 | |||
TMEM205 Antibody (B-5) FITC | sc-514568 FITC | 200 µg/ml | $330.00 | |||
TMEM205 Antibody (B-5) PE | sc-514568 PE | 200 µg/ml | $343.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 488 | sc-514568 AF488 | 200 µg/ml | $357.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 546 | sc-514568 AF546 | 200 µg/ml | $357.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 594 | sc-514568 AF594 | 200 µg/ml | $357.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 647 | sc-514568 AF647 | 200 µg/ml | $357.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 680 | sc-514568 AF680 | 200 µg/ml | $357.00 | |||
TMEM205 Antibody (B-5) Alexa Fluor® 790 | sc-514568 AF790 | 200 µg/ml | $357.00 |