TMEFF1 Antibody (H-11): sc-393005
- TMEFF1 Antibody (H-11) is a mouse monoclonal mouse IgG2b κ κ provided at 200 µg/ml
- raised against amino acids 204-260 mapping within an internal region of TMEFF1 of human origin
- recommended for detection of TMEFF1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMEFF1 Antibody (H-11) for WB applications. These reagents are now offered in bundles with TMEFF1 Antibody (H-11) (see ordering information below).
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TMEFF1 Antibody (H-11) is a mouse monoclonal IgG2b antibody that detects TMEFF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMEFF1 is a putative transmembrane protein characterized by a unique structure that includes one epidermal growth factor (EGF)-like domain and two follistatin-like domains, which are crucial for cellular signaling. TMEFF1 is predominantly expressed in the brain and is believed to play a significant role as a tumor suppressor gene in brain cancers. The highly conserved cytoplasmic tail of TMEFF1, along with its extracellular modified EGF domain, allows interaction with various signaling pathways, particularly by inhibiting nodal signaling through binding to Cripto, a nodal co-receptor. This interaction helps regulate bone morphogenetic proteins (BMPs), which are essential for numerous developmental processes. TMEFF1′s ability to modulate these pathways underscores its importance in maintaining cellular homeostasis and potential implications in cancer biology, making anti-TMEFF1 antibody (H-11) an invaluable tool for researchers studying these critical mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEFF1 Antibody (H-11) | sc-393005 | 200 µg/ml | $322.00 | |||
TMEFF1 Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-538116 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMEFF1 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-535671 | 200 µg Ab; 40 µg BP | $361.00 |