TMEFF1 Antibody (B-4): sc-393457
- TMEFF1 Antibody (B-4) is a mouse monoclonal IgG2b κ TMEFF1 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 222-247 within an internal region of TMEFF1 of human origin
- TMEFF1 Antibody (B-4) is recommended for detection of TMEFF1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMEFF1 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMEFF1 Antibody (B-4) for WB applications. These reagents are now offered in bundles with TMEFF1 Antibody (B-4) (see ordering information below).
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TMEFF1 Antibody (B-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects TMEFF1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-TMEFF1 antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMEFF1 is a putative transmembrane protein characterized by a unique structure that includes one epidermal growth factor (EGF)-like domain and two follistatin-like domains, which are crucial for cellular signaling function. Located predominantly in the brain, TMEFF1 plays a significant role in modulating signaling pathways, particularly by inhibiting nodal signaling through interaction with Cripto, a nodal co-receptor. This interaction suggests a potential tumor suppressor function for TMEFF1 in brain cancers, where TMEFF1 may help regulate bone morphogenetic proteins (BMPs) and contribute to the overall balance of growth factors in the neural environment. A highly conserved cytoplasmic tail of TMEFF1 further underscores TMEFF1′s importance in cellular communication and signaling, making TMEFF1 (B-4) monoclonal antibody an essential tool for researchers studying cancer biology and neurodevelopment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMEFF1 Antibody (B-4) References:
- Expression of TMEFF1 mRNA in the mouse central nervous system: precise examination and comparative studies of TMEFF1 and TMEFF2. | Kanemoto, N., et al. 2001. Brain Res Mol Brain Res. 86: 48-55. PMID: 11165370
- The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development. | Morais da Silva, S., et al. 2001. Mech Dev. 104: 125-8. PMID: 11404089
- Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms. | Chang, C., et al. 2003. Dev Biol. 255: 1-11. PMID: 12618130
- TMEFF1 and brain tumors. | Gery, S., et al. 2003. Oncogene. 22: 2723-7. PMID: 12743596
- Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. | Harms, PW. and Chang, C. 2003. Genes Dev. 17: 2624-9. PMID: 14563676
- Protein interaction analysis of ST14 domains and their point and deletion mutants. | Ge, W., et al. 2006. J Biol Chem. 281: 7406-12. PMID: 16407223
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMEFF1 Antibody (B-4) | sc-393457 | 200 µg/ml | $316.00 | |||
TMEFF1 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-530462 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEFF1 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-523953 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMEFF1 Antibody (B-4): m-IgG2b BP-HRP Bundle | sc-550191 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMEFF1 Antibody (B-4) AC | sc-393457 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMEFF1 Antibody (B-4) HRP | sc-393457 HRP | 200 µg/ml | $316.00 | |||
TMEFF1 Antibody (B-4) FITC | sc-393457 FITC | 200 µg/ml | $330.00 | |||
TMEFF1 Antibody (B-4) PE | sc-393457 PE | 200 µg/ml | $343.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 488 | sc-393457 AF488 | 200 µg/ml | $357.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 546 | sc-393457 AF546 | 200 µg/ml | $357.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 594 | sc-393457 AF594 | 200 µg/ml | $357.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 647 | sc-393457 AF647 | 200 µg/ml | $357.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 680 | sc-393457 AF680 | 200 µg/ml | $357.00 | |||
TMEFF1 Antibody (B-4) Alexa Fluor® 790 | sc-393457 AF790 | 200 µg/ml | $357.00 | |||
TMEFF1 (B-4) Neutralizing Peptide | sc-393457 P | 100 µg/0.5 ml | $68.00 |