TMC6 Antibody (H-10): sc-376679
- TMC6 Antibody (H-10) is a mouse monoclonal IgG2a κ TMC6 antibody provided at 200 µg/ml
- raised against amino acids 311-420 mapping within an internal region of TMC6 of human origin
- TMC6 Antibody (H-10) is recommended for detection of TMC6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMC6 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMC6 Antibody (H-10) for WB applications. These reagents are now offered in bundles with TMC6 Antibody (H-10) (see ordering information below).
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TMC6 Antibody (H-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects TMC6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TMC6 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMC6, also known as transmembrane channel-like 6, EVER1, EVIN1, EV1, or LAK-4P, is an 805 amino acid multi-pass membrane protein primarily localized to the endoplasmic reticulum, a critical site for protein folding and processing. This localization is essential as TMC6 plays a significant role in regulating calcium homeostasis and ion transport across the membrane, which are vital for various cellular functions. TMC6 is expressed in tissues such as testis, placenta, and prostate, and exists in multiple alternatively spliced isoforms. Defects in TMC6 are linked to epidermodysplasia verruciformis, an autosomal recessive dermatosis characterized by heightened susceptibility to human papillomaviruses and increased risk of squamous cell carcinoma in UV-exposed skin. The gene encoding TMC6 is located on human chromosome 17, which encompasses over 2.5% of the human genome and encodes more than 1,200 genes, highlighting TMC6′s significance in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMC6 Antibody (H-10) References:
- A susceptibility locus for epidermodysplasia verruciformis, an abnormal predisposition to infection with the oncogenic human papillomavirus type 5, maps to chromosome 17qter in a region containing a psoriasis locus. | Ramoz, N., et al. 1999. J Invest Dermatol. 112: 259-63. PMID: 10084299
- Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. | Ramoz, N., et al. 2000. J Invest Dermatol. 114: 1148-53. PMID: 10844558
- TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. | Keresztes, G., et al. 2003. BMC Genomics. 4: 24. PMID: 12812529
- Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. | Kurima, K., et al. 2003. Genomics. 82: 300-8. PMID: 12906855
- Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis. | Tate, G., et al. 2004. J Hum Genet. 49: 223-225. PMID: 15042430
- Four mutations in Epidermodysplasia verruciformis 1 (EVER1) gene are not contributors to susceptibility in RRP. | Donfack, J., et al. 2006. Int J Pediatr Otorhinolaryngol. 70: 1235-40. PMID: 16487602
- Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. | Lazarczyk, M., et al. 2008. J Exp Med. 205: 35-42. PMID: 18158319
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMC6 Antibody (H-10) | sc-376679 | 200 µg/ml | $322.00 | |||
TMC6 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-529919 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMC6 Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-523042 | 200 µg Ab, 40 µg BP | $361.00 | |||
TMC6 Antibody (H-10): m-IgG2a BP-HRP Bundle | sc-547400 | 200 µg Ab; 10 µg BP | $361.00 | |||
TMC6 Antibody (H-10) AC | sc-376679 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TMC6 Antibody (H-10) HRP | sc-376679 HRP | 200 µg/ml | $322.00 | |||
TMC6 Antibody (H-10) FITC | sc-376679 FITC | 200 µg/ml | $336.00 | |||
TMC6 Antibody (H-10) PE | sc-376679 PE | 200 µg/ml | $349.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 488 | sc-376679 AF488 | 200 µg/ml | $364.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 546 | sc-376679 AF546 | 200 µg/ml | $364.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 594 | sc-376679 AF594 | 200 µg/ml | $364.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 647 | sc-376679 AF647 | 200 µg/ml | $364.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 680 | sc-376679 AF680 | 200 µg/ml | $364.00 | |||
TMC6 Antibody (H-10) Alexa Fluor® 790 | sc-376679 AF790 | 200 µg/ml | $364.00 |