TLR7 Antibody (4F4): sc-57463

TLR7 Antibody (4F4) is a mouse monoclonal IgG1 kappa light chain antibody that detects TLR7 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-TLR7 antibody (4F4) is available as the non-conjugated format. TLR7 plays a crucial role in the innate immune system by recognizing single-stranded RNA, which is often associated with viral infections. Upon activation, TLR7 initiates a signaling cascade that leads to the production of pro-inflammatory cytokines and type I interferons, essential for mounting an effective immune response. This function is particularly important in the context of viral infections, as TLR7 helps the body detect and respond to pathogens early in the infection process. TLR7 is predominantly expressed in immune-related tissues such as the lung, placenta, and spleen, where TLR7 contributes to the regulation of immune responses. Anti-TLR7 antibody (4F4) serves as a valuable tool for researchers studying immune mechanisms and potential therapeutic targets in viral infections, particularly given TLR7′s ability to activate the NFκB signaling pathway and mediate inflammation.

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TLR7 Antibody (4F4) References:

1. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.  |  Brightbill, HD., et al. 1999. Science. 285: 732-6. PMID: 10426995
2. Three novel mammalian toll-like receptors: gene structure, expression, and evolution.  |  Du, X., et al. 2000. Eur Cytokine Netw. 11: 362-71. PMID: 11022119
3. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.  |  Chuang, TH. and Ulevitch, RJ. 2000. Eur Cytokine Netw. 11: 372-8. PMID: 11022120
4. Drosophila Toll and IL-1 receptor.  |  Gay, NJ. and Keith, FJ. 1991. Nature. 351: 355-6. PMID: 1851964
5. EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production.  |  Luo, Z., et al. 2019. PLoS Pathog. 15: e1008142. PMID: 31730654
6. TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.  |  Heinz, LX., et al. 2020. Nature. 581: 316-322. PMID: 32433612
7. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.  |  Zhu, Y., et al. 2022. EMBO Mol Med. 14: e14455. PMID: 34936223
8. TLR7 gain-of-function genetic variation causes human lupus.  |  Brown, GJ., et al. 2022. Nature. 605: 349-356. PMID: 35477763
9. The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE.  |  Crawford, JD., et al. 2023. JCI Insight. 8: PMID: 37733447
10. UNC93B1 variants underlie TLR7-dependent autoimmunity.  |  Wolf, C., et al. 2024. Sci Immunol. 9: eadi9769. PMID: 38207055
11. Neuronal substance P drives metastasis through an extracellular RNA-TLR7 axis.  |  Padmanaban, V., et al. 2024. Nature. 633: 207-215. PMID: 39112700
12. A family of human receptors structurally related to Drosophila Toll.  |  Rock, FL., et al. 1998. Proc Natl Acad Sci U S A. 95: 588-93. PMID: 9435236

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR7 Antibody (4F4) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR7 Antibody (4F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR7 Antibody (4F4) Specifications

Alternate Product Name: TLR7

Product Clone Name: 4F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 451-500

Epitope Target: TLR7

Epitope Species: human

Product Reactivity/Detection: TLR7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for TLR7 Antibody (4F4): N/A

The preferred TLR7 antibody is TLR7 Antibody (C-1): sc-518178.