TLR7 Antibody (C-1): sc-518178
- TLR7 Antibody (C-1) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 44-69 within an N-terminal extracellular domain of TLR7 of human origin
- recommended for detection of TLR7 of human origin by WB, IP, IF and ELISA
- Anti-TLR7 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TLR7 Antibody (C-1) for WB applications. This reagent is now offered in a bundle with TLR7 Antibody (C-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
TLR7 Antibody (C-1) is a mouse monoclonal IgM antibody that detects TLR7 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TLR7 (C-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Toll-like Receptors (TLRs) are a critical family of receptors in the human immune system, sharing homology with the Drosophila Toll Receptors, which are essential for mediating dorsoventral polarization during embryonic development in Drosophila and play a significant role in host immunity. TLR7 recognizes single-stranded RNA, which is crucial for detecting viral infections and initiating an immune response. TLR7 is predominantly expressed in the lung, placenta, and spleen, and activation leads to stimulation of the NFκB signaling pathway, highlighting TLR7′s importance in orchestrating the immune response against pathogens. The highly conserved Toll homology (TH) domain within TLR7 is essential for signal transduction, allowing effective communication with downstream signaling molecules. Understanding TLR7 function and expression is vital for developing therapeutic strategies targeting immune responses, particularly in viral infections and autoimmune diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TLR7 Antibody (C-1) References:
- Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. | Diebold, SS., et al. 2004. Science. 303: 1529-31. PMID: 14976261
- TLR-7 and -8 agonists as vaccine adjuvants. | Tomai, MA. and Vasilakos, JP. 2011. Expert Rev Vaccines. 10: 405-7. PMID: 21506636
- Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. | Goel, RR., et al. 2020. Proc Natl Acad Sci U S A. 117: 5409-5419. PMID: 32094169
- Potential value of pharmacological agents acting on toll-like receptor (TLR) 7 and/or TLR8 in COVID-19. | Khalifa, AE. and Ghoneim, AI. 2021. Curr Res Pharmacol Drug Discov. 2: 100068. PMID: 34870161
- TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension. | Yeh, FC., et al. 2023. Eur Respir J. 62: PMID: 37290790
- TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. | Shibata, T., et al. 2023. J Exp Med. 220: PMID: 37462944
- TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity. | Jackson, WD., et al. 2023. Elife. 12: PMID: 37566453
- B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice. | Cosgrove, HA., et al. 2023. JCI Insight. 8: PMID: 37606042
- Disrupted degradative sorting of TLR7 is associated with human lupus. | Mishra, H., et al. 2024. Sci Immunol. 9: eadi9575. PMID: 38207015
- Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation. | Bérouti, M., et al. 2024. Immunity. 57: 1482-1496.e8. PMID: 38697119
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLR7 Antibody (C-1) | sc-518178 | 200 µg/ml | $322.00 | |||
TLR7 Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-550705 | 200 µg Ab; 40 µg BP | $361.00 | |||
TLR7 Antibody (C-1) AC | sc-518178 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TLR7 Antibody (C-1) HRP | sc-518178 HRP | 200 µg/ml | $322.00 | |||
TLR7 Antibody (C-1) FITC | sc-518178 FITC | 200 µg/ml | $336.00 | |||
TLR7 Antibody (C-1) PE | sc-518178 PE | 200 µg/ml | $349.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 488 | sc-518178 AF488 | 200 µg/ml | $364.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 546 | sc-518178 AF546 | 200 µg/ml | $364.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 594 | sc-518178 AF594 | 200 µg/ml | $364.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 647 | sc-518178 AF647 | 200 µg/ml | $364.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 680 | sc-518178 AF680 | 200 µg/ml | $364.00 | |||
TLR7 Antibody (C-1) Alexa Fluor® 790 | sc-518178 AF790 | 200 µg/ml | $364.00 |