TLR5 Antibody (C7): sc-517439

TLR5 Antibody (C7) is a mouse monoclonal IgG2b kappa light chain antibody that detects TLR5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TLR5 antibody (C7) is available as the non-conjugated format. TLR5 protein plays a crucial role in the innate immune system by recognizing bacterial flagellin, which is a key component of bacterial flagella. This recognition triggers a signaling cascade that leads to the activation of immune responses, including the production of pro-inflammatory cytokines. TLR5′s ability to detect flagellated bacteria is vital for initiating an effective immune response, thereby helping to protect the host from infections. TLR5 is predominantly expressed in immune cells, particularly in monocytes, and is also found in tissues such as the ovary, prostate, and testis. Expression in these areas underscores TLR5′s importance in both local and systemic immune responses, making TLR5 a significant target for research in immunology and infectious diseases.

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TLR5 Antibody (C7) References:

1. Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin.  |  Tsujita, T., et al. 2006. Vaccine. 24: 2193-9. PMID: 16314010
2. AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2.  |  McNamara, N., et al. 2006. Am J Respir Cell Mol Biol. 34: 653-60. PMID: 16439799
3. Decreased Toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients.  |  Stanislawowski, M., et al. 2009. J Physiol Pharmacol. 60 Suppl 4: 71-5. PMID: 20083854
4. TLR-4, TLR-5 and IRF4 are diagnostic markers of knee osteoarthritis in the middle-aged and elderly patients and related to disease activity and inflammatory factors.  |  Han, W., et al. 2020. Exp Ther Med. 20: 1291-1298. PMID: 32765669
5. Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.  |  Kurz, B., et al. 2022. J Eur Acad Dermatol Venereol. 36: 2172-2180. PMID: 35748133
6. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease.  |  Shen, Z., et al. 2022. EBioMedicine. 85: 104285. PMID: 36182776
7. A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins.  |  Kosten, TR., et al. 2022. Vaccines (Basel). 10: PMID: 36298456
8. TLR5-Derived, TIR-Interacting Decoy Peptides to Inhibit TLR Signaling.  |  Javmen, A., et al. 2023. J Immunol. 210: 1419-1427. PMID: 36946775
9. TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity.  |  Feng, S., et al. 2023. J Inflamm Res. 16: 2491-2501. PMID: 37337514
10. Mucosal TLR5 activation controls healthspan and longevity.  |  Lim, JS., et al. 2024. Nat Commun. 15: 46. PMID: 38167804

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR5 Antibody (C7) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR5 Antibody (C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR5 Antibody (C7) Specifications

Alternate Product Name: TLR5

Product Clone Name: C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 693-858

Epitope Target: TLR5

Epitope Species: human

Product Reactivity/Detection: TLR5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for TLR5 Antibody (C7): N/A

The preferred TLR5 antibody is TLR5 Antibody (H-11): sc-518106.