TIRAP Antibody (C-7): sc-166150
- TIRAP Antibody (C-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-235 representing full length TIRAP of human origin
- recommended for detection of TIRAP of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TIRAP Antibody (C-7) for WB applications. These reagents are now offered in bundles with TIRAP Antibody (C-7) (see ordering information below).
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TIRAP Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects TIRAP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIRAP, also known as MyD88 adapter-like protein, plays a crucial role in the innate immune response by acting as a signaling adapter that links Toll-like receptors (TLRs) to downstream signaling pathways, including the activation of NFκB and mitogen-activated protein kinases. TIRAP is primarily located in the cytoplasm, where TIRAP forms homodimers and heterodimers with MyD88, facilitating the recruitment of interleukin-1 receptor-associated kinases (IRAKs) to TLRs. Proper localization of TIRAP is essential for effective signal transduction, as TIRAP ensures that the immune response is activated promptly upon recognition of microbial products. Dysregulation of TIRAP function can lead to impaired immune responses, making TIRAP a critical component in the study of immune system disorders and potential therapeutic targets. Anti-TIRAP antibody (C-7) is an invaluable tool for researchers investigating the mechanisms of TLR signaling and its implications in various diseases.
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TIRAP Antibody (C-7) References:
- Aberrant TIRAP and MyD88 expression in B-cell chronic lymphocytic leukemia. | Antosz, H., et al. 2013. Blood Cells Mol Dis. 51: 48-55. PMID: 23419703
- Particle-Induced Osteolysis Is Mediated by TIRAP/Mal in Vitro and in Vivo: Dependence on Adherent Pathogen-Associated Molecular Patterns. | Bechtel, CP., et al. 2016. J Bone Joint Surg Am. 98: 285-94. PMID: 26888676
- Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif. | Zhao, X., et al. 2017. Sci Rep. 7: 43043. PMID: 28225045
- mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression. | Imanishi, T., et al. 2020. Cell Rep. 32: 107911. PMID: 32698010
- Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection. | Fulgione, A., et al. 2020. Sci Rep. 10: 15831. PMID: 32985578
- Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19. | Traets, MJM., et al. 2022. PLoS One. 17: e0260897. PMID: 34995294
- TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells. | Nilsen, KE., et al. 2022. Biomedicines. 10: PMID: 35884781
- TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms and Their Association with Cervical Cancer Phenotype and Prognosis. | Bekampytė, J., et al. 2022. Genes (Basel). 13: PMID: 36011276
- ALKBH5-mediated m6 A demethylation of TIRAP mRNA promotes radiation-induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma. | Chen, Y., et al. 2023. Clin Transl Med. 13: e1198. PMID: 36792369
- Dorzolamide suppresses PKCδ -TIRAP-p38 MAPK signaling axis to dampen the inflammatory response. | Rajpoot, S., et al. 2023. Future Med Chem.. PMID: 37129027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIRAP Antibody (C-7) | sc-166150 | 200 µg/ml | $322.00 | |||
TIRAP Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-540027 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIRAP Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-541855 | 200 µg Ab; 20 µg BP | $361.00 |