TIRAP Antibody (B-3): sc-166151

TIRAP Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects TIRAP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIRAP, also known as MyD88 adapter-like protein, plays a crucial role in the innate immune response by acting as a signaling adapter that links Toll-like receptors (TLRs) to downstream signaling pathways, including the activation of NFκB and mitogen-activated protein kinases. TIRAP is primarily located in the cytoplasm, where TIRAP forms homodimers and heterodimers with MyD88, facilitating the recruitment of interleukin-1 receptor-associated kinases (IRAKs) to TLRs. Proper functioning of TIRAP is vital for effective immune responses, as TIRAP ensures rapid activation of inflammatory pathways in response to microbial infections. Dysregulation of TIRAP signaling can lead to impaired immune responses or excessive inflammation, highlighting TIRAP′s importance in maintaining immune homeostasis. Anti-TIRAP antibody (B-3) is an essential tool for researchers studying the mechanisms of immune signaling and the role of TIRAP in various diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TIRAP Antibody (B-3) References:

1. Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups.  |  Dissanayeke, SR., et al. 2009. PLoS One. 4: e6698. PMID: 19693265
2. Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.  |  Gandhi, A., et al. 2013. Toxicol Appl Pharmacol. 266: 430-8. PMID: 23238562
3. TLR4/TIRAP polymorphisms are associated with progression and survival of patients with symptomatic myeloma.  |  Bagratuni, T., et al. 2016. Br J Haematol. 172: 44-7. PMID: 26564000
4. Heterozygous mutants of TIRAP (S180L) polymorphism protect adult patients with Plasmodium falciparum infection against severe disease and mortality.  |  Panda, AK., et al. 2016. Infect Genet Evol. 43: 146-50. PMID: 27166096
5. Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses.  |  Srivastava, M., et al. 2019. Int Immunopharmacol. 71: 188-197. PMID: 30909134
6. MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients.  |  Saranathan, R., et al. 2020. Infect Genet Evol. 77: 104093. PMID: 31678649
7. The αC helix of TIRAP holds therapeutic potential in TLR-mediated autoimmune diseases.  |  Shah, M., et al. 2020. Biomaterials. 245: 119974. PMID: 32220799
8. Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling.  |  Li, X., et al. 2020. Int J Mol Sci. 21: PMID: 32357531
9. Protective role of TIRAP functional variant against development of coronary artery disease.  |  Noreen, M., et al. 2021. Saudi J Biol Sci. 28: 3548-3552. PMID: 34121897
10. Identification of novel inhibitors targeting TIRAP interactions with BTK and PKCδ in inflammation through an in silico approach.  |  Rajpoot, S., et al. 2022. SAR QSAR Environ Res. 33: 141-166. PMID: 35174746

The preferred TIRAP antibody is TIRAP Antibody (A-11): sc-166149.