TIMP-3 Antibody (E-2): sc-373842
- TIMP-3 Antibody (E-2) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 181-210 at the C-terminus of TIMP-3 of human origin
- recommended for detection of TIMP-3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TIMP-3 Antibody (E-2) for WB applications. This reagent is now offered in a bundle with TIMP-3 Antibody (E-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TIMP-3 Antibody (E-2) is a mouse monoclonal IgG3 antibody that detects TIMP-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIMP-3 plays a crucial role in regulating extracellular matrix remodeling by inhibiting metalloproteinases, which are enzymes responsible for the degradation of various components of the extracellular matrix. This regulation is vital for maintaining tissue homeostasis and facilitating processes such as wound healing and tissue repair. TIMP-3 is unique among the tissue inhibitors of metalloproteinases due to its ability to bind to and inhibit a wide range of metalloproteinases, including those involved in pathological conditions like cancer metastasis and tissue fibrosis. TIMP-3 expression is particularly significant in tumor biology, as TIMP-3 can influence tumor progression and metastasis by modulating the tumor microenvironment. With diverse applications and a critical role in cellular processes, anti-TIMP-3 antibody (E-2) serves as an essential tool for researchers studying the dynamics of extracellular matrix interactions and their implications in health and disease.
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TIMP-3 Antibody (E-2) References:
- Expression and inhibitory role of TIMP-3 in hepatocellular carcinoma. | Shen, B., et al. 2016. Oncol Rep. 36: 494-502. PMID: 27222429
- TIMP-3 Increases the Chemosensitivity of Laryngeal Carcinoma to Cisplatin via Facilitating Mitochondria-Dependent Apoptosis. | Shen, X., et al. 2018. Oncol Res. 27: 73-80. PMID: 29523219
- Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. | English, WR., et al. 2018. PLoS One. 13: e0195116. PMID: 29617412
- Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding. | Spanò, DP. and Scilabra, SD. 2022. Membranes (Basel). 12: PMID: 35207132
- Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Disease. | Park, JH., et al. 2022. J Pers Med. 12: PMID: 35629249
- Association of tissue inhibitor of metalloproteinase-3 (TIMP-3) serum level and its genetic polymorphism with pregnancy outcome of patients undergoing in vitro fertilization and embryo transfer. | Meraji Masouleh Moghaddam, M., et al. 2023. Ginekol Pol. 94: 400-406. PMID: 35894478
- Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis. | Tayman, MA. and Koyuncu, İ. 2023. Biotech Histochem. 98: 126-131. PMID: 36093887
- Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer. | Zhou, Y., et al. 2023. Pharmacol Res. 194: 106846. PMID: 37414199
- Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm. | Hu, M., et al. 2023. J Mol Cell Cardiol. 184: 61-74. PMID: 37844423
- Associations between genetically predicted TIMP-3 levels and risk of venous thromboembolism: A two sample Mendelian randomization study. | Li, Y., et al. 2024. J Pharm Biomed Anal. 248: 116290. PMID: 38878456
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIMP-3 Antibody (E-2) | sc-373842 | 200 µg/ml | $322.00 | |||
TIMP-3 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-522527 | 200 µg Ab, 40 µg BP | $361.00 | |||
TIMP-3 (E-2) Neutralizing Peptide | sc-373842 P | 100 µg/0.5 ml | $69.00 |