TIMP-3 Activators
TIMP-3 Activators refer to a class of compounds or molecules that enhance or stimulate the activity of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3). The TIMP family, including TIMP-3, serves crucial roles in regulating the activities of matrix metalloproteinases (MMPs), which are zinc-dependent endopeptidases involved in the degradation of the extracellular matrix. As a result, TIMP-3 plays a pivotal role in maintaining the balance of tissue remodeling, angiogenesis, and a host of other cellular processes by ensuring that MMP activity is kept in check.
The uniqueness of TIMP-3 compared to other members of the TIMP family lies in its ability to bind not just to active MMPs, but also to a subset of disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes. This broad spectrum of inhibition gives TIMP-3 a distinct physiological importance. The activation of TIMP-3 by specific activators can augment its natural inhibitory action, thereby influencing a myriad of physiological pathways and cellular events. It's noteworthy to mention that while the exact mechanisms by which these activators work can be multifaceted, they all converge on the common goal of either increasing TIMP-3 expression or its effective activity. With the interplay between TIMPs and MMPs being pivotal in various biological processes, understanding and studying TIMP-3 activators becomes paramount for deeper insights into tissue homeostasis and cellular dynamics.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A. It can influence cellular differentiation and has been shown to modulate TIMP-3 expression, potentially through nuclear receptors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that can demethylate DNA. By affecting DNA methylation, it might upregulate the expression of genes, including TIMP-3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound from turmeric. It has anti-inflammatory properties and can potentially induce TIMP-3 expression through its effects on cellular signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a soy isoflavone that has antioxidant properties. It may stimulate TIMP-3 expression by influencing various intracellular signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a compound found in grapes, can activate sirtuin pathways and might influence TIMP-3 expression through its antioxidant and anti-inflammatory effects. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is found in cruciferous vegetables. It may enhance TIMP-3 expression due to its capability to modulate various cellular stress and detoxification pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties. It could induce TIMP-3 expression by affecting cellular redox status and modulating signaling pathways. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $109.00 $387.00 | 5 | |
6-Gingerol is an active compound from ginger. It might stimulate TIMP-3 expression due to its anti-inflammatory and antioxidant properties. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide, a reactive oxygen species, can affect cellular signaling. Its role in TIMP-3 induction may relate to oxidative stress responses in cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid. It may induce TIMP-3 expression by interacting with glucocorticoid receptors and modulating downstream signaling pathways. | ||||||