TIG2 Antibody (E-7): sc-373797
- TIG2 Antibody (E-7) is a mouse monoclonal IgG1 κ TIG2 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 21-163 mapping at the C-terminus of TIG2 of human origin
- TIG2 Antibody (E-7) is recommended for detection of TIG2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TIG2 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TIG2 Antibody (E-7) for WB and IHC(P) applications. These reagents are now offered in bundles with TIG2 Antibody (E-7) (see ordering information below).
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TIG2 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects TIG2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TIG2 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TIG2, a member of the Tazarotene-induced gene family, plays a crucial role as a secreted protein primarily expressed in the epidermis, hair follicles, and endothelial cells, where TIG2 functions as a tumor suppressor. TIG2 expression is notably inhibited in psoriatic lesions, highlighting TIG2′s importance in skin health and disease. TIG2 is activated by tazarotene, a synthetic retinoid, which underscores TIG2′s role in mediating the growth-suppressive effects of retinoids. TIG2′s ability to interact with retinoic acid receptors and retinoid X receptors further emphasizes TIG2′s significance in regulating cellular growth and differentiation, making TIG2 a vital target for research in cancer biology and dermatological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TIG2 Antibody (E-7) References:
- Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. | Youssef, EM., et al. 2004. Cancer Res. 64: 2411-7. PMID: 15059893
- Optimal use of a panel of methylation markers with GSTP1 hypermethylation in the diagnosis of prostate adenocarcinoma. | Tokumaru, Y., et al. 2004. Clin Cancer Res. 10: 5518-22. PMID: 15328191
- Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. | Kwong, J., et al. 2005. Int J Cancer. 113: 386-92. PMID: 15455391
- An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. | Aagaard, A., et al. 2005. Structure. 13: 309-17. PMID: 15698574
- Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. | Takai, N., et al. 2005. Mol Cancer Res. 3: 261-9. PMID: 15886297
- Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. | DiSepio, D., et al. 1998. Proc Natl Acad Sci U S A. 95: 14811-5. PMID: 9843971
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIG2 Antibody (E-7) | sc-373797 | 200 µg/ml | $322.00 | |||
TIG2 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-529566 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIG2 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-522503 | 200 µg Ab, 40 µg BP | $361.00 | |||
TIG2 Antibody (E-7): m-IgG1 BP-HRP Bundle | sc-543582 | 200 µg Ab; 20 µg BP | $361.00 | |||
TIG2 Antibody (E-7) AC | sc-373797 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TIG2 Antibody (E-7) HRP | sc-373797 HRP | 200 µg/ml | $322.00 | |||
TIG2 Antibody (E-7) FITC | sc-373797 FITC | 200 µg/ml | $336.00 | |||
TIG2 Antibody (E-7) PE | sc-373797 PE | 200 µg/ml | $349.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 488 | sc-373797 AF488 | 200 µg/ml | $364.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 546 | sc-373797 AF546 | 200 µg/ml | $364.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 594 | sc-373797 AF594 | 200 µg/ml | $364.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 647 | sc-373797 AF647 | 200 µg/ml | $364.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 680 | sc-373797 AF680 | 200 µg/ml | $364.00 | |||
TIG2 Antibody (E-7) Alexa Fluor® 790 | sc-373797 AF790 | 200 µg/ml | $364.00 |