TIG2 Inhibitors
TIG2 inhibitors belong to a distinctive chemical class designed to modulate the activity of the TIG2 protein. TIG2, short for Tazarotene-induced gene 2, is a member of the adipose triglyceride lipase (ATGL) family, primarily expressed in adipose tissues. The protein plays a crucial role in lipid metabolism, particularly in the hydrolysis of triglycerides into free fatty acids and glycerol. TIG2 inhibition, therefore, represents a targeted approach to intervene in lipid catabolism pathways, potentially influencing energy homeostasis and metabolic processes.
TIG2 inhibitors are meticulously designed small molecules that interact with the active sites of the TIG2 protein, disrupting its enzymatic function. The inhibition of TIG2 activity may lead to altered lipid profiles and intracellular lipid storage dynamics, impacting cellular energy balance. Researchers are keenly investigating the structural features of TIG2 inhibitors to optimize their potency and selectivity, aiming to unveil the intricate mechanisms underlying lipid metabolism regulation. Understanding the pharmacokinetic and pharmacodynamic properties of these inhibitors is crucial for unraveling their potential impact on cellular processes and may open avenues for further exploration in the broader context of metabolic research. The intricate interplay between TIG2 inhibitors and lipid metabolism provides a fascinating focal point for ongoing studies in the quest for a deeper comprehension of cellular dynamics and the development of novel chemical tools for scientific investigations.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
Acitretin is a synthetic retinoid. It can bind to retinoid receptors, altering gene expression and potentially inhibiting the effects of proteins induced by other retinoids. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a terpenoid with retinoid antagonist activity. It can inhibit retinoid action by competing with retinoids for their receptors. | ||||||
CH 55 | 110368-33-7 | sc-203884 sc-203884A | 10 mg 50 mg | $141.00 $599.00 | ||
Ch55 is a synthetic retinoid that acts as an antagonist. It can inhibit retinoid-responsive gene expression and therefore inhibit the action of proteins upregulated by retinoids. | ||||||
LE 135 | 155877-83-1 | sc-204053 sc-204053A | 10 mg 50 mg | $168.00 $707.00 | 5 | |
LE135 is a naphthalene derivative that acts as a selective antagonist of retinoic acid receptors, particularly RAR-beta, which may downregulate the activity of proteins modulated by retinoids. | ||||||
LG 100268 | 153559-76-3 | sc-211737 | 5 mg | $390.00 | 2 | |
LG100268 is a synthetic retinoid X receptor (RXR) selective ligand that can inhibit the activity of proteins involved in the RXR pathway. | ||||||
SR 11237 | 146670-40-8 | sc-296418 sc-296418A | 5 mg 50 mg | $211.00 $877.00 | ||
SR11237 is a synthetic retinoid that acts as an RXR antagonist. It can inhibit the transcriptional activity regulated by RXRs. | ||||||
BMS 493 | 215030-90-3 | sc-361124 sc-361124A | 10 mg 50 mg | $459.00 $1428.00 | 7 | |
BMS493 is an inverse agonist of retinoic acid receptors, which can inhibit the function of proteins that are typically induced by retinoids. | ||||||
TTNPB | 71441-28-6 | sc-203303 sc-203303A sc-203303B | 10 mg 25 mg 50 mg | $210.00 $347.00 $640.00 | 20 | |
Arotinoid acid is a retinoid analog that acts as an antagonist to retinoid receptors, influencing gene expression and protein activity associated with these receptors. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide is a synthetic retinoid that can modulate gene expression by binding to retinoid receptors, thereby influencing the activity of proteins that are regulated by retinoid signaling pathways. | ||||||