TIA-1 Antibody (G-11): sc-365349
- TIA-1 Antibody (G-11) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 349-381 near the C-terminus of TIA-1 of human origin
- recommended for detection of TIA-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See TIA-1 (G-3): sc-166247 for TIA-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TIA-1 Antibody (G-11) for WB applications. This reagent is now offered in a bundle with TIA-1 Antibody (G-11) (see ordering information below).
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TIA-1 Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects TIA-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIA-1, a crucial type I transmembrane protein, is primarily located in the nucleus and plays a significant role in regulating apoptotic cell death, particularly in response to FAS signaling. This localization enables TIA-1 to participate in the post-transcriptional regulation of gene expression during apoptosis, influencing the fate of cells under stress or damage. Upon FAS ligation, TIA-1 rapidly translocates to the cytoplasm, where TIA-1 interacts with various signaling molecules, including the serine/threonine kinase FAST, which activates during this process. The phosphorylation state of TIA-1 is critical for function, as phosphorylation modulates RNA binding ability and regulates the expression of pro-apoptotic factors. Anti-TIA-1 antibody (G-11) serves as an essential tool for researchers studying apoptosis mechanisms and intricate signaling pathways involved in immune responses, providing insights into potential therapeutic targets for diseases characterized by dysregulated cell death.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIA-1 Antibody (G-11) | sc-365349 | 200 µg/ml | $322.00 | |||
TIA-1 Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-540329 | 200 µg Ab; 10 µg BP | $361.00 | |||
TIA-1 (G-11) Neutralizing Peptide | sc-365349 P | 100 µg/0.5 ml | $69.00 |