Thrombospondin 4 Antibody (G-10): sc-28293
- Thrombospondin 4 Antibody (G-10) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 141-240 of Thrombospondin 4 of human origin
- recommended for detection of Thrombospondin 4 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Thrombospondin 4 Antibody (G-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Thrombospondin 4 Antibody (G-10) (see ordering information below).
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Thrombospondin 4 Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects Thrombospondin 4 (THBS4) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). THBS4 is primarily expressed in the nervous system and plays a crucial role in neuronal development and repair, particularly by stimulating neurite outgrowth, which is essential for the formation of neural networks and the recovery of damaged neurons. THBS4′s ability to promote neurite extension is vital for proper neuronal connectivity and function, making THBS4 a key player in neurodevelopmental processes and potential therapeutic target for neurodegenerative diseases. THBS4 also interacts with various extracellular matrix components and growth factors, further underscoring THBS4′s importance in cellular signaling and tissue repair mechanisms. Anti-THBS4 antibody (G-10) is an invaluable tool for researchers studying the intricate roles of THBS4 in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Thrombospondin 4 Antibody (G-10) References:
- Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. | Misenheimer, TM. and Mosher, DF. 2005. J Biol Chem. 280: 41229-35. PMID: 16246837
- Janus face of thrombospondin-4: impairs small artery vasodilation but protects against cardiac hypertrophy and aortic aneurysm formation. | Sure, VN. and Katakam, PV. 2016. Am J Physiol Heart Circ Physiol. 310: H1383-4. PMID: 27106043
- Central Mechanisms Mediating Thrombospondin-4-induced Pain States. | Park, J., et al. 2016. J Biol Chem. 291: 13335-48. PMID: 27129212
- Thrombospondin-4 mediates TGF-β-induced angiogenesis. | Muppala, S., et al. 2017. Oncogene. 36: 5189-5198. PMID: 28481870
- Thrombospondin-4 critically controls transforming growth factor β1 induced hypertrophic scar formation. | Qian, W., et al. 2018. J Cell Physiol. 234: 731-739. PMID: 30132849
- Thrombospondin-4 increases with the severity of peripheral arterial disease and is associated with diabetes. | Zierfuss, B., et al. 2020. Heart Vessels. 35: 52-58. PMID: 31227875
- Thrombospondin-4 mediates hyperglycemia- and TGF-beta-induced inflammation in breast cancer. | Muppala, S., et al. 2021. Int J Cancer. 148: 2010-2022. PMID: 33320955
- Pathophysiological roles of thrombospondin-4 in disease development. | Genaro, K. and Luo, ZD. 2024. Semin Cell Dev Biol. 155: 66-73. PMID: 37391348
- Thrombospondin 4, a mediator and candidate indicator of pain. | Wu, Y., et al. 2024. Eur J Cell Biol. 103: 151395. PMID: 38340499
- The role and mechanism of thrombospondin-4 in pulmonary arterial hypertension associated with congenital heart disease. | Zeng, H., et al. 2024. Respir Res. 25: 313. PMID: 39154161
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thrombospondin 4 Antibody (G-10) | sc-28293 | 200 µg/ml | $316.00 | |||
Thrombospondin 4 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-538916 | 200 µg Ab; 10 µg BP | $354.00 | |||
Thrombospondin 4 Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-541146 | 200 µg Ab; 20 µg BP | $354.00 |