Thrombospondin 1 Antibody (SPM321): sc-65612

Thrombospondin 1 Antibody (SPM321) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to recognize Thrombospondin 1 (TSP-1), also known as CD36 ligand or cartilage-derived retinoic acid-sensitive protein (CD-RAP) in cartilage-related studies. Anti-Thrombospondin 1 antibody (SPM321) is raised against reduced and alkylated purified human Thrombospondin 1, ensuring robust recognition of both reduced and fully denatured forms. Thrombospondin 1 is a multifunctional extracellular glycoprotein that undergoes critical post-translational modifications, including extensive glycosylation, which are essential for stability, secretion, and interactions with cell surface receptors such as CD36 and integrins. These post-translational modifications enable TSP-1 to regulate key biological processes such as platelet aggregation, cellular adhesion, migration, and tissue remodeling, making TSP-1 a vital component in both physiological and pathological contexts. Thrombospondin 1 (SPM321) antibody demonstrates broad species reactivity, effectively detecting TSP-1 from mouse, rat, human, ovine, equine, bovine, porcine, and canine origins across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). By targeting post-translationally modified forms of TSP-1, anti-Thrombospondin 1 antibody (SPM321) allows researchers to investigate functional implications of these modifications in cellular processes and disease mechanisms. Thrombospondin 1 (SPM321) monoclonal antibody is an indispensable tool for advancing studies in cellular biology, regenerative medicine, and oncology, providing critical insights into dynamic roles of TSP-1 in maintaining cellular homeostasis and mediating tissue responses to injury.

The preferred Thrombospondin 1 antibody is Thrombospondin 1 Antibody (A6.1): sc-59887.