THEM2 Antibody (B-12): sc-373696
- THEM2 Antibody (B-12) is a mouse monoclonal IgG2b κ THEM2 antibody provided at 200 µg/ml
- raised against amino acids 53-140 mapping at the C-terminus of THEM2 of human origin
- THEM2 Antibody (B-12) is recommended for detection of THEM2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-THEM2 Antibody (B-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for THEM2 Antibody (B-12) for WB and IHC(P) applications. These reagents are now offered in bundles with THEM2 Antibody (B-12) (see ordering information below).
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THEM2 Antibody (B-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects THEM2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). THEM2 (B-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. THEM2, also known as thioesterase superfamily member 2, is a 140 amino acid protein that plays a crucial role in lipid metabolism by hydrolyzing thioester bonds, which is essential for the regulation of fatty acid and lipid homeostasis within cells. This function is particularly important as dysregulation of lipid metabolism is linked to various metabolic disorders and diseases, including obesity and diabetes. Highly expressed in the kidney and moderately in the brain, liver, and intestines, THEM2 co-localizes with microtubules, potentially influencing cellular proliferation and signaling pathways. The gene encoding THEM2 is located on chromosome 6, a region associated with several genetic disorders, including early onset intestinal cancer and other conditions such as Porphyria cutanea tarda and Parkinson′s disease, highlighting THEM2′s significance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
THEM2 Antibody (B-12) References:
- The DNA sequence and analysis of human chromosome 6. | Mungall, AJ., et al. 2003. Nature. 425: 805-11. PMID: 14574404
- HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. | Lucas, B., et al. 2005. Oncogene. 24: 6418-31. PMID: 16007190
- Crystal structure of human thioesterase superfamily member 2. | Cheng, Z., et al. 2006. Biochem Biophys Res Commun. 349: 172-7. PMID: 16934754
- Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule. | Cheng, Z., et al. 2006. Biochem Biophys Res Commun. 350: 850-3. PMID: 17045243
- Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2. | Kanno, K., et al. 2007. J Biol Chem. 282: 30728-36. PMID: 17704541
- HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. | Grigo, K., et al. 2008. Biol Chem. 389: 179-87. PMID: 18163890
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
THEM2 Antibody (B-12) | sc-373696 | 200 µg/ml | $322.00 | |||
THEM2 Antibody (B-12): m-IgGκ BP-HRP Bundle | sc-522461 | 200 µg Ab, 40 µg BP | $361.00 | |||
THEM2 Antibody (B-12): m-IgG2b BP-HRP Bundle | sc-549034 | 200 µg Ab; 10 µg BP | $361.00 | |||
THEM2 Antibody (B-12) AC | sc-373696 AC | 500 µg/ml, 25% agarose | $424.00 | |||
THEM2 Antibody (B-12) HRP | sc-373696 HRP | 200 µg/ml | $322.00 | |||
THEM2 Antibody (B-12) FITC | sc-373696 FITC | 200 µg/ml | $336.00 | |||
THEM2 Antibody (B-12) PE | sc-373696 PE | 200 µg/ml | $349.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 488 | sc-373696 AF488 | 200 µg/ml | $364.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 546 | sc-373696 AF546 | 200 µg/ml | $364.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 594 | sc-373696 AF594 | 200 µg/ml | $364.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 647 | sc-373696 AF647 | 200 µg/ml | $364.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 680 | sc-373696 AF680 | 200 µg/ml | $364.00 | |||
THEM2 Antibody (B-12) Alexa Fluor® 790 | sc-373696 AF790 | 200 µg/ml | $364.00 |