THEM2 Inhibitors
THEM2 Inhibitors comprises compounds that indirectly affect the function of the protein THEM2 by modulating lipid metabolism processes that THEM2 is believed to be involved in. These compounds exert their influence through various mechanisms, such as inhibition of enzymes responsible for the transportation and breakdown of fatty acids, modulation of transcription factors that regulate lipid metabolism, and alteration of metabolite levels that control key metabolic pathways.
The compounds mentioned, such as etomoxir and trimetazidine, act by inhibiting enzymes directly involved in mitochondrial fatty acid oxidation, thus altering the lipid metabolism landscape in which THEM2 operates. Other compounds, such as perhexiline and oxfenicine, similarly target enzymes in fatty acid metabolism and can thereby influence THEM2's function. Malonyl-CoA, a metabolite that regulates fatty acid oxidation, also plays a role in this regulatory network by inhibiting CPT1, a critical enzyme in the transport of fatty acids into the mitochondria for oxidation. Furthermore, chemicals like fenofibrate, WY-14643, GW7647, and Medica 16 function through activation or inhibition of PPARα, a nuclear receptor that plays a pivotal role in the regulation of fatty acid storage and metabolism. By activating PPARα, these compounds can induce
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $151.00 $506.00 | 3 | |
Inhibits carnitine palmitoyltransferase 1 (CPT1) on the outer mitochondrial membrane, reducing fatty acid entry into mitochondria for β-oxidation, which can downregulate fatty acid oxidation that THEM2 may be involved in. | ||||||
1-(2,3,4-Trimethoxybenzyl)piperazine | 5011-34-7 | sc-297236 | 500 mg | $374.00 | ||
Inhibits long-chain 3-ketoacyl CoA thiolase, which is involved in the final step of β-oxidation. By reducing fatty acid oxidation, it may indirectly affect THEM2 function which is linked to lipid metabolism. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Activates peroxisome proliferator-activated receptor alpha (PPARα), leading to increased fatty acid oxidation in peroxisomes. This modulation of lipid metabolism can indirectly affect THEM2 activities. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
Agonist of peroxisome proliferator-activated receptor alpha (PPARα), potentially enhancing lipid catabolism in peroxisomes and indirectly influencing THEM2 functions. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
A potent PPARα agonist that can enhance fatty acid catabolism, indirectly impacting THEM2's role in lipid metabolism. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Increases NAD+ levels, which can modulate sirtuin activity and mitochondrial function, thereby potentially influencing fatty acid oxidation and indirectly affecting THEM2's role in lipid metabolism. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Exhibits multiple modes of action, including activation of AMP-activated protein kinase (AMPK), which can enhance fatty acid oxidation and regulate lipid metabolism, indirectly influencing THEM2's activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
A fibrate drug that acts as a ligand for PPARα, leading to altered lipid homeostasis, which indirectly impacts THEM2's role in lipid metabolism. | ||||||