Molecular structure of GW 7647, CAS Number: 265129-71-3
GW 7647 (CAS 265129-71-3)
See product citations (6)
Alternate Names:
2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid; GW7647
Application:
GW 7647 is a potent PPARα agonist with 200-fold selectivity over PPARγ and PPARδ
CAS Number:
265129-71-3
Purity:
>98%
Molecular Weight:
502.8
Molecular Formula:
C29H46N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 7647 is a potent PPARalpha agonist with 200-fold selectivity over PPARgamma and PPARdelta. This compound has also been found to cause an up-regulation of beta-oxidation gene expression and an increase in palmitate oxidation. Additionally, glycolysis is strongly reduced at transcriptional levels by GW 7647 leading to a decrease in lactate and pyruvate production. Furthermore, this agent displays the ability to decrease glucose oxidation and inhibit lipogenesis and triglyceride esterification.
GW 7647 (CAS 265129-71-3) References
- Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. | Gupta, RA., et al. 2000. Proc Natl Acad Sci U S A. 97: 13275-80. PMID: 11087869
- Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. | Brown, PJ., et al. 2001. Bioorg Med Chem Lett. 11: 1225-7. PMID: 11354382
- Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. | Cunard, R., et al. 2002. J Immunol. 168: 2795-802. PMID: 11884448
- Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy. | Rampler, H., et al. 2003. Mol Genet Metab. 80: 398-407. PMID: 14654352
- PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. | Paukkeri, EL., et al. 2007. Br J Pharmacol. 152: 1081-91. PMID: 17891158
- Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes. | Ribet, C., et al. 2010. Endocrinology. 151: 123-33. PMID: 19887568
- Differential regulation of stimulated glucose transport by free fatty acids and PPARα or -Δ agonists in cardiac myocytes. | Asrih, M., et al. 2012. Am J Physiol Endocrinol Metab. 302: E872-84. PMID: 22297301
- Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. | Nayeem, MA., et al. 2013. Am J Physiol Regul Integr Comp Physiol. 304: R23-32. PMID: 23152114
- Long-term stability of primary rat hepatocytes in micropatterned cocultures. | Ukairo, O., et al. 2013. J Biochem Mol Toxicol. 27: 204-12. PMID: 23315828
- Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment. | Lebeck, J., et al. 2015. Am J Physiol Gastrointest Liver Physiol. 308: G198-205. PMID: 25477377
- Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo. | Liu, ZQ., et al. 2018. Autophagy. 14: 1011-1027. PMID: 29771182
- Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue. | Rebello, CJ., et al. 2019. Obesity (Silver Spring). 27: 103-111. PMID: 30506905
- A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities. | Peiretti, F., et al. 2020. J Med Chem. 63: 13124-13139. PMID: 33142057
Inhibitor of:
2200002K05Rik, ACOX3, ACSM2A, BNIP-2, ECSIT, HkRP3, HSDL2, ILBP, L-FABP, Lipocalin-15, Lipocalin-9, MC3-R, MC5-R, Melanocortin receptor (MC-R), Peroxin 11β, Pxmp2, SCD5, T-FABP, THEM2, THEM5, and USP25.Activator of:
17β-HSD11, 2900097C17Rik, ABHD14A, ACAA2, ACOT5, ACOT6, ACOX1, ACSL1, ACSL6, ACSM2A, ACSM5, AKR1CL2, apoM, Bex6, C16orf61, C17orf63, Calpain II, CES3, ChREBP, CIDE-C, CPTI-L, Cyp2c39, Cyp2c40, Cyp2c54, CYP4A10, CYP4A11, CYP4A29, CYP4A30B, EG330305, EG546325, EG625716, EG668114, FADS1, FAS, FATP-1, FATP4, GK3P, Gm749, GS2, Lipin-3, LPAAT-η, MBOAT4, MLYCD, NDRG2, PECI, Peroxin 16, Peroxin 7, PPAR alpha, SH3TC1, SREB1, StARD9, STRAD, Tim10, and Unc79.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 7647, 1 mg | sc-203068A | 1 mg | $49.00 | |||
GW 7647, 5 mg | sc-203068 | 5 mg | $170.00 | |||
GW 7647, 10 mg | sc-203068B | 10 mg | $267.00 | |||
GW 7647, 25 mg | sc-203068C | 25 mg | $661.00 |