TH-POK Antibody (C-8): sc-398509
- TH-POK Antibody (C-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 71-102 within an internal region of TH-POK of human origin
- recommended for detection of TH-POK of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-398509 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TH-POK Antibody (C-8) for WB applications. These reagents are now offered in bundles with TH-POK Antibody (C-8) (see ordering information below).
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TH-POK Antibody (C-8) is a mouse monoclonal IgG2a antibody that detects TH-POK in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TH-POK, also known as zinc finger protein 67 (ZFP67), is a 539 amino acid protein characterized by one BTB (POZ) domain and four C2H2-type zinc fingers, which are crucial for its function as a transcriptional regulator. TH-POK (C-8) antibody targets a protein primarily localized in the nucleus, where TH-POK plays a vital role in determining the lineage commitment of immature T-cell precursors. Specifically, TH-POK is essential for guiding positively selected thymocytes towards the CD4 lineage; absence of TH-POK leads to a default development into the CD8 lineage. Furthermore, TH-POK acts as a transcriptional repressor for several genes, including COL1A1, COL1A2, and fibronectin, highlighting TH-POK′s importance in T-cell differentiation and immune response regulation. TH-POK (C-8) antibody′s versatility in various applications makes anti-TH-POK antibody (C-8) an invaluable tool for researchers studying T-cell biology and related immunological processes.
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TH-POK Antibody (C-8) References:
- The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. | He, X., et al. 2005. Nature. 433: 826-33. PMID: 15729333
- Regulation of Th-POK and Runx3 in T cell development in human thymoma. | Tokunaga, T., et al. 2009. Autoimmunity. 42: 653-60. PMID: 19886737
- Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells. | Hu, J., et al. 2010. PLoS One. 5: e8891. PMID: 20126642
- Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection. | Engel, I., et al. 2010. J Exp Med. 207: 1015-29. PMID: 20404101
- Identification of important regulatory region of Th-POK. | Shamsul Alam, M. 2010. J Med Invest. 57: 219-23. PMID: 20847520
- Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision. | Sato, T., et al. 2012. J Immunol. 189: 4426-36. PMID: 23018457
- The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells. | Engel, I., et al. 2012. Blood. 120: 4524-32. PMID: 23034280
- ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells. | Enders, A., et al. 2012. J Immunol. 189: 5240-9. PMID: 23105140
- TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells. | Steinke, FC., et al. 2014. Nat Immunol. 15: 646-656. PMID: 24836425
- Th-POK regulates mammary gland lactation through mTOR-SREBP pathway. | Zhang, R., et al. 2018. PLoS Genet. 14: e1007211. PMID: 29420538
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TH-POK Antibody (C-8) | sc-398509 | 200 µg/ml | $322.00 | |||
TH-POK Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-540937 | 200 µg Ab; 10 µg BP | $361.00 | |||
TH-POK Antibody (C-8): m-IgG2a BP-HRP Bundle | sc-546982 | 200 µg Ab; 10 µg BP | $361.00 | |||
TH-POK (C-8) Neutralizing Peptide | sc-398509 P | 100 µg/0.5 ml | $69.00 | |||
TH-POK Antibody (C-8) X | sc-398509 X | 200 µg/0.1 ml | $322.00 |