TGF beta 1 Antibody (TB21): sc-52893

TGFβ1 Antibody (TB21) is a mouse monoclonal IgG1 kappa light chain antibody that detects TGFβ1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-TGFβ1 antibody (TB21) is available in a non-conjugated form, specifically designed for researchers studying transforming growth factor beta 1, which plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and immune responses. TGFβ1 is primarily secreted by platelets and found in the extracellular matrix, where TGFβ1 modulates cell signaling pathways governing tissue repair and fibrosis. TGFβ1 undergoes several post-translational modifications, including glycosylation and phosphorylation, which significantly influence activity and stability. These modifications are essential for proper TGFβ1 functioning, affecting interactions with specific receptors and other proteins, ultimately impacting developmental processes and disease states. The mature form of TGFβ1 is biologically active only when dimerized, highlighting the importance of structural integrity for effective signaling. With an ability to mediate critical cellular interactions, TGFβ1 is a key player in both normal physiological processes and pathological conditions, making TGFβ1 monoclonal antibody (TB21) an invaluable tool for investigating diverse roles in health and disease.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TGF beta 1 Antibody (TB21) has 102 citations in a variety of scientific publications.

Primary antibodies like Anti-TGF beta 1 Antibody (TB21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TGF beta 1 Antibody (TB21) Specifications

Alternate Product Name: TGFB1

Product Clone Name: TB21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: TGFβ1

Epitope Species: human

Product Reactivity/Detection: natural and recombinant TGFβ1, both dimeric and monomeric natural forms under reducing and non reducing conditions

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 102 citations in various scientific publications

Available Conjugates/Forms for TGF beta 1 Antibody (TB21): N/A

The preferred TGF beta 1 antibody is TGF beta 1 Antibody (3C11): sc-130348.