TGF beta 1 Antibody (3C11): sc-130348

TGFβ1 Antibody (3C11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TGFβ1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-TGFβ1 antibody (3C11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transforming growth factor beta 1 (TGFβ1) plays a crucial role in regulating cell growth, differentiation, and immune responses, making TGFβ1 essential for maintaining tissue homeostasis and mediating various physiological processes. TGFβ1 is primarily secreted by platelets and is found in the extracellular matrix, where TGFβ1 exists in a latent form bound to its latency-associated peptide. Upon activation, TGFβ1 can influence the behavior of numerous cell types, including fibroblasts, epithelial cells, and immune cells, thereby impacting processes such as wound healing, fibrosis, and immune regulation. TGFβ1′s ability to modulate these cellular interactions underscores TGFβ1′s importance in both normal physiological functions and pathological conditions, including cancer and autoimmune diseases.

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TGF beta 1 Antibody (3C11) References:

1. TGFbeta1, back to the future: revisiting its role as a transforming growth factor.  |  Glick, AB. 2004. Cancer Biol Ther. 3: 276-83. PMID: 15034302
2. Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling.  |  Scherner, O., et al. 2007. J Biol Chem. 282: 13934-43. PMID: 17376778
3. Transforming growth factor-beta. A family of growth regulatory peptides.  |  Miller, DA., et al. 1990. Ann N Y Acad Sci. 593: 208-17. PMID: 2375595
4. Molecular characterization of transforming growth factor type beta 3.  |  ten Dijke, P., et al. 1990. Ann N Y Acad Sci. 593: 26-42. PMID: 2375596
5. A key role for TGF-β1 in hippocampal synaptic plasticity and memory.  |  Caraci, F., et al. 2015. Sci Rep. 5: 11252. PMID: 26059637
6. Recombinant TGF-beta 1 is synthesized as a two-component latent complex that shares some structural features with the native platelet latent TGF-beta 1 complex.  |  Wakefield, LM., et al. 1989. Growth Factors. 1: 203-18. PMID: 2629880
7. Identification of another member of the transforming growth factor type beta gene family.  |  ten Dijke, P., et al. 1988. Proc Natl Acad Sci U S A. 85: 4715-9. PMID: 3164476
8. Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.  |  de Martin, R., et al. 1987. EMBO J. 6: 3673-7. PMID: 3322813
9. TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels.  |  Virk, HS., et al. 2021. Br J Pharmacol. 178: 2948-2962. PMID: 33786825
10. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.  |  Derynck, R., et al. Nature. 316: 701-5. PMID: 3861940
11. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.  |  Todaro, GJ., et al. 1980. Proc Natl Acad Sci U S A. 77: 5258-62. PMID: 6254071
12. Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.  |  Anzano, MA., et al. 1983. Proc Natl Acad Sci U S A. 80: 6264-8. PMID: 6604914

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TGF beta 1 Antibody (3C11) has 298 citations in a variety of scientific publications.

Primary antibodies like Anti-TGF beta 1 Antibody (3C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TGF beta 1 Antibody (3C11) Specifications

Alternate Product Name: TGFβ1

Product Clone Name: 3C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: TGFβ1

Epitope Species: human

Product Reactivity/Detection: TGFβ1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 298 citations in various scientific publications

Available Conjugates/Forms for TGF beta 1 Antibody (3C11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin