TGase4 Antibody (C-12): sc-398627

TGase4 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects TGase4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TGase4, also known as TGM4, TGP, or hTGP, plays a crucial role in the formation of the cross-linked cell envelope, a vital component of the epidermis that provides structural integrity and barrier function to the skin. TGase4 is specifically expressed in prostate tissue and is involved in the catalysis of isopeptide bond formation, which is essential for the cross-linking of proteins during epidermal differentiation. TGase4 activity influences various biological processes, including cell differentiation and apoptosis, thereby contributing to the maintenance of tissue homeostasis and the regulation of cellular functions. Anti-TGase4 antibody (C-12) is an invaluable tool for researchers studying the role of transglutaminases in skin biology and prostate tissue, enabling the exploration of its implications in health and disease.

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TGase4 Antibody (C-12) References:

1. Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer.  |  Davies, G., et al. 2007. J Exp Ther Oncol. 6: 257-64. PMID: 17552366
2. The prostate transglutaminase (TGase-4, TGaseP) regulates the interaction of prostate cancer and vascular endothelial cells, a potential role for the ROCK pathway.  |  Jiang, WG., et al. 2009. Microvasc Res. 77: 150-7. PMID: 18983858
3. The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells.  |  Jiang, WG., et al. 2010. Int J Oncol. 37: 413-8. PMID: 20596668
4. Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer.  |  Ablin, RJ., et al. 2011. J Transl Med. 9: 49. PMID: 21524313
5. Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain.  |  Jiang, WG., et al. 2013. J Transl Med. 11: 269. PMID: 24161123
6. Transglutaminase 4 as a prostate autoantigen in male subfertility.  |  Landegren, N., et al. 2015. Sci Transl Med. 7: 292ra101. PMID: 26084804
7. Prostate Transglutaminase (TGase-4) Induces Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells.  |  Ablin, RJ., et al. 2017. Anticancer Res. 37: 481-487. PMID: 28179293
8. Enhancement of Cartilage Regeneration of Synovial Stem Cells/Hydrogel by Using Transglutaminase-4.  |  Kim, JK., et al. 2021. Tissue Eng Part A. 27: 761-770. PMID: 33107390
9. Biochemical Characterisation of Human Transglutaminase 4.  |  Csobán-Szabó, Z., et al. 2021. Int J Mol Sci. 22: PMID: 34830327
10. Transglutaminase-4 (Prostate Transglutaminase), a Potential Biological Factor and Clinical Indicator for the Diagnosis and Prognosis of Prostate Cancer.  |  Ye, L., et al. 2023. Anticancer Res. 43: 291-296. PMID: 36585193

The preferred TGase4 antibody is TGase4 Antibody (E-10): sc-271382.