TGase2 Antibody (4G3): sc-73612
- TGase2 Antibody (4G3) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against red blood cell transglutaminase of human origin
- TGase2 Antibody (4G3) is recommended for detection of TGase2 first binding domain of mouse, rat, human origin by WB, IP, IF and IHC(P); non cross-reactive with other transglutaminases
- Anti-TGase2 Antibody (4G3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for inhibition of cell adhesion, sc-73612 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TGase2 Antibody (4G3) for WB and IHC(P) applications. These reagents are now offered in bundles with TGase2 Antibody (4G3) (see ordering information below).
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TGase2 Antibody (4G3) is a mouse monoclonal IgG1 kappa light chain antibody that detects TGase2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-TGase2 antibody (4G3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TGase2 plays a crucial role in cellular processes by catalyzing the formation of isopeptide bonds, which are essential for cross-linking proteins through the action of transglutaminases. This enzymatic activity is vital for the formation of the cross-linked cell envelope, a key structural component of the epidermis that provides mechanical strength and barrier function to the skin. The cross-linked cell envelope is generated through the formation of disulfide bonds and γ-glutamyl-lysine isodipeptide bonds, which are critical for maintaining the integrity of the epidermis during processes such as differentiation and wound healing. Additionally, TGase2 is involved in various biological functions, including blood coagulation, cell differentiation, and apoptosis, highlighting its importance in both normal physiology and pathological conditions. TGase2 (4G3) monoclonal antibody recognizes the first binding domain of TGase2, making this antibody an invaluable tool for researchers studying the diverse roles of TGase2 in cellular biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TGase2 Antibody (4G3) References:
- Transglutaminase 2 in neurodegenerative disorders. | Ruan, Q. and Johnson, GV. 2007. Front Biosci. 12: 891-904. PMID: 17127346
- Physiopathological roles of human transglutaminase 2. | Gentile, V. 2011. Adv Enzymol Relat Areas Mol Biol. 78: 47-95. PMID: 22220472
- Versatility of microbial transglutaminase. | Strop, P. 2014. Bioconjug Chem. 25: 855-62. PMID: 24694238
- Biological functionalities of transglutaminase 2 and the possibility of its compensation by other members of the transglutaminase family. | Odii, BO. and Coussons, P. 2014. ScientificWorldJournal. 2014: 714561. PMID: 24778599
- Inhibitors of tissue transglutaminase. | Keillor, JW., et al. 2015. Trends Pharmacol Sci. 36: 32-40. PMID: 25500711
- Transglutaminase inhibitors: a patent review. | Keillor, JW. and Apperley, KY. 2016. Expert Opin Ther Pat. 26: 49-63. PMID: 26560530
- Microbial transglutaminase for biotechnological and biomedical engineering. | Deweid, L., et al. 2019. Biol Chem. 400: 257-274. PMID: 30291779
- The Outside-In Journey of Tissue Transglutaminase in Cancer. | Sima, LE., et al. 2022. Cells. 11: PMID: 35681474
- Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis. | Das, S., et al. 2023. Adv Sci (Weinh). 10: e2300401. PMID: 37424036
- Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype. | Gates, EWJ., et al. 2023. Int J Mol Sci. 24: PMID: 37628729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TGase2 Antibody (4G3) | sc-73612 | 200 µg/ml | $322.00 | |||
TGase2 Antibody (4G3): m-IgG Fc BP-HRP Bundle | sc-527009 | 200 µg Ab; 10 µg BP | $361.00 | |||
TGase2 Antibody (4G3): m-IgG1 BP-HRP Bundle | sc-532382 | 200 µg Ab; 20 µg BP | $361.00 | |||
TGase2 Antibody (4G3) L | sc-73612 L | 200 µg/0.1 ml | $322.00 | |||
TGase2 Antibody (4G3) AC | sc-73612 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TGase2 Antibody (4G3) HRP | sc-73612 HRP | 200 µg/ml | $322.00 | |||
TGase2 Antibody (4G3) FITC | sc-73612 FITC | 200 µg/ml | $336.00 | |||
TGase2 Antibody (4G3) PE | sc-73612 PE | 200 µg/ml | $349.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 488 | sc-73612 AF488 | 200 µg/ml | $364.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 546 | sc-73612 AF546 | 200 µg/ml | $364.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 594 | sc-73612 AF594 | 200 µg/ml | $364.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 647 | sc-73612 AF647 | 200 µg/ml | $364.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 680 | sc-73612 AF680 | 200 µg/ml | $364.00 | |||
TGase2 Antibody (4G3) Alexa Fluor® 790 | sc-73612 AF790 | 200 µg/ml | $364.00 |