TFR2 Antibody (9F8 1C11): sc-32271

TFR2 Antibody (9F8 1C11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TFR2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-TFR2 antibody (9F8 1C11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transferrin receptor 2 (TFR2) plays a crucial role in iron metabolism by mediating the uptake of transferrin-bound iron, which is essential for numerous biological processes, including oxygen transport and DNA synthesis. TFR2 is predominantly expressed in the liver, particularly in hepatocytes and erythroid precursors, highlighting its importance in maintaining iron homeostasis and supporting erythrocyte differentiation. The gene encoding human TFR2 is located on chromosome 7q22 and produces two isoforms: an α isoform that encodes a transmembrane protein and a β isoform that encodes a shorter, intracellular protein. Dysregulation or mutations in TFR2 can lead to hereditary hemochromatosis type III (HFE3), a serious iron overload disorder associated with significant clinical complications such as cirrhosis, cardiomyopathy, diabetes, endocrine dysfunctions, arthropathy, and an increased risk of liver cancer. Using TFR2 monoclonal antibody (9F8 1C11) in research can provide valuable insights into iron metabolism mechanisms and the pathophysiology of related disorders.

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TFR2 Antibody (9F8 1C11) References:

1. The roles of iron in health and disease.  |  Lieu, PT., et al. 2001. Mol Aspects Med. 22: 1-87. PMID: 11207374
2. New mutations inactivating transferrin receptor 2 in hemochromatosis type 3.  |  Roetto, A., et al. 2001. Blood. 97: 2555-60. PMID: 11313241
3. Regulation of expression of murine transferrin receptor 2.  |  Kawabata, H., et al. 2001. Blood. 98: 1949-54. PMID: 11535534
4. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells.  |  Kawabata, H., et al. 2001. Blood. 98: 2714-9. PMID: 11675342
5. Haemochromatosis: understanding the mechanism of disease and implications for diagnosis and patient management following the recent cloning of novel genes involved in iron metabolism.  |  Fletcher, LM. and Halliday, JW. 2002. J Intern Med. 251: 181-92. PMID: 11886477
6. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum.  |  Deaglio, S., et al. 2002. Blood. 100: 3782-9. PMID: 12393650
7. Genetic haemochromatosis: genes and mutations associated with iron loading.  |  Camaschella, C., et al. 2002. Best Pract Res Clin Haematol. 15: 261-76. PMID: 12401307
8. The extrahepatic role of TFR2 in iron homeostasis.  |  Silvestri, L., et al. 2014. Front Pharmacol. 5: 93. PMID: 24847265
9. TFR2 regulates ferroptosis and enhances temozolomide chemo-sensitization in gliomas.  |  Tong, S., et al. 2023. Exp Cell Res. 424: 113474. PMID: 36702193
10. EZH2 suppresses ferroptosis in hepatocellular carcinoma and reduces sorafenib sensitivity through epigenetic regulation of TFR2.  |  Lai, Y., et al. 2024. Cancer Sci. 115: 2220-2234. PMID: 38623968
11. Bone marrow Tfr2 deletion improves the therapeutic efficacy of the activin-receptor ligand trap RAP-536 in β-thalassemic mice.  |  Tanzi, E., et al. 2024. Am J Hematol. 99: 1313-1325. PMID: 38629683
12. TFR2 gene alterations in idiopathic erythrocytosis reinforce a possible relation between erythrocytosis and iron metabolism.  |  Benetti, A., et al. 2025. Genes Dis. 12: 101291. PMID: 39386104

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TFR2 Antibody (9F8 1C11) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-TFR2 Antibody (9F8 1C11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TFR2 Antibody (9F8 1C11) Specifications

Alternate Product Name: Transferrin Receptor 2

Product Clone Name: 9F8 1C11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: TFR2

Epitope Species: human

Product Reactivity/Detection: TFR2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for TFR2 Antibody (9F8 1C11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin