TFIIB Antibody (IIB8): sc-23875
- TFIIB Antibody (IIB8) is a mouse monoclonal IgG2a κ, cited in 11 publications, provided at 200 µg/ml
- raised against partially purified recombinant human TFIIB, epitope maps to amino acids 52-105
- recommended for detection of TFIIB of mouse, rat and human origin by WB and IP
- TransCruz reagent for Gel Supershift and ChIP applications (sc-23875 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TFIIB Antibody (IIB8) for WB applications. These reagents are now offered in bundles with TFIIB Antibody (IIB8) (see ordering information below).
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SEE ALSO...
TFIIB Antibody (IIB8) is a mouse monoclonal IgG2a antibody that detects TFIIB in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). TFIIB plays a crucial role in transcription initiation by serving as a bridge between TATA-binding protein (TBP) and RNA polymerase II, facilitating assembly of the transcription pre-initiation complex. This interaction ensures RNA polymerase II is properly positioned at the promoter region, allowing for correct initiation of RNA synthesis. TFIIB′s role extends beyond structural support, influencing recruitment of additional transcription factors and overall regulation of gene expression. By understanding TFIIB′s function and interactions within transcription machinery, researchers can gain insights into mechanisms of gene regulation and potential implications in various biological processes and diseases. Anti-TFIIB antibody (IIB8) serves as an essential tool for studying these complex interactions and advancing knowledge in molecular biology.
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TFIIB Antibody (IIB8) References:
- TFIIB and the regulation of transcription by RNA polymerase II. | Deng, W. and Roberts, SG. 2007. Chromosoma. 116: 417-29. PMID: 17593382
- Revealing the functions of TFIIB. | Weinzierl, RO. and Wiesler, SC. 2011. Transcription. 2: 254-7. PMID: 22223047
- TFIIB-related factors in RNA polymerase I transcription. | Knutson, BA. and Hahn, S. 2013. Biochim Biophys Acta. 1829: 265-73. PMID: 22960599
- Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. | Haas, DA., et al. 2018. PLoS Pathog. 14: e1006980. PMID: 29709033
- Expansion and Functional Diversification of TFIIB-Like Factors in Plants. | Ning, H., et al. 2021. Int J Mol Sci. 22: PMID: 33498602
- Critical Involvement of TFIIB in Viral Pathogenesis. | O'Brien, MJ. and Ansari, A. 2021. Front Mol Biosci. 8: 669044. PMID: 33996913
- Beyond the canonical role of TFIIB in eukaryotic transcription. | O'Brien, MJ. and Ansari, A. 2022. Curr Genet. 68: 61-67. PMID: 34797379
- RNA Polymerase II Transcription in Pneumocystis: TFIIB from Pneumocystis carinii Can Replace the Transcriptional Functions of Fission Yeast Schizosaccharomyces pombe TFIIB In Vivo and In Vitro. | Rojas, DA., et al. 2022. Int J Mol Sci. 23: PMID: 35743306
- Genome-wide analysis of TFIIB's role in termination of transcription. | O'Brien, MJ., et al. 2024. bioRxiv.. PMID: 38915573
- TFIIB-Termination Factor Interaction Affects Termination of Transcription on Genome-Wide Scale. | O'Brien, MJ., et al. 2024. Int J Mol Sci. 25: PMID: 39201330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFIIB Antibody (IIB8) | sc-23875 | 200 µg/ml | $322.00 | |||
TFIIB Antibody (IIB8): m-IgG Fc BP-HRP Bundle | sc-536681 | 200 µg Ab; 10 µg BP | $361.00 | |||
TFIIB Antibody (IIB8): m-IgGκ BP-HRP Bundle | sc-533840 | 200 µg Ab; 40 µg BP | $361.00 | |||
TFIIB Antibody (IIB8): m-IgG2a BP-HRP Bundle | sc-547845 | 200 µg Ab; 10 µg BP | $361.00 | |||
TFIIB Antibody (IIB8) X | sc-23875 X | 200 µg/0.1 ml | $322.00 |