Testican-1 Antibody (C-3): sc-390789
- Testican-1 Antibody (C-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 161-238 mapping within an internal region of Testican-1 of human origin
- Testican-1 Antibody (C-3) is recommended for detection of Testican-1 of human origin by WB, IP, IF and ELISA
- Anti-Testican-1 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Testican-1 Antibody (C-3) for WB applications. These reagents are now offered in bundles with Testican-1 Antibody (C-3) (see ordering information below).
QUICK LINKS
Testican-1 Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Testican-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Testican-1 (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Testican-1 is a member of the Testican family, which is part of the larger BM-40/SPARC/osteonectin family of highly conserved, extracellular, calcium-binding sulfate proteoglycans. Testican-1 plays a crucial role in the central nervous system, particularly in the thalamus, where Testican-1 is upregulated in activated astroglial cells following neural injury, such as a cerebral stroke. Testican-1 upregulation in astrocytes mediates neuronal attachment and influences matrix metalloproteinase activation, which is essential for tissue remodeling and repair. Testican-1 is involved in the regulation of matrix turnover in joint and growth plate cartilage, highlighting Testican-1′s importance in both neural and skeletal health. Testican-1′s ability to inhibit matrix metalloproteinases, particularly pro-MMP-2, underscores Testican-1′s role in modulating extracellular matrix dynamics, making Testican-1 a vital target for research in neurobiology and tissue regeneration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Testican-1 Antibody (C-3) References:
- Testican-1 inhibits attachment of Neuro-2a cells. | Marr, HS. and Edgell, CJ. 2003. Matrix Biol. 22: 259-66. PMID: 12853036
- Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L. | Bocock, JP., et al. 2003. Eur J Biochem. 270: 4008-15. PMID: 14511383
- Testican-1: a differentially expressed proteoglycan with protease inhibiting activities. | Edgell, CJ., et al. 2004. Int Rev Cytol. 236: 101-22. PMID: 15261737
- Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage. | Hausser, HJ., et al. 2004. Osteoarthritis Cartilage. 12: 870-7. PMID: 15501402
- SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer. | Mohrmann, G., et al. 2005. Int J Cancer. 116: 547-54. PMID: 15825179
- Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L. | Meh, P., et al. 2005. Biol Chem. 386: 75-83. PMID: 15843150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Testican-1 Antibody (C-3) | sc-390789 | 200 µg/ml | $322.00 | |||
Testican-1 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-530262 | 200 µg Ab; 10 µg BP | $361.00 | |||
Testican-1 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-523683 | 200 µg Ab, 40 µg BP | $361.00 | |||
Testican-1 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-543961 | 200 µg Ab; 20 µg BP | $361.00 | |||
Testican-1 Antibody (C-3) AC | sc-390789 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Testican-1 Antibody (C-3) HRP | sc-390789 HRP | 200 µg/ml | $322.00 | |||
Testican-1 Antibody (C-3) FITC | sc-390789 FITC | 200 µg/ml | $336.00 | |||
Testican-1 Antibody (C-3) PE | sc-390789 PE | 200 µg/ml | $349.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 488 | sc-390789 AF488 | 200 µg/ml | $364.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 546 | sc-390789 AF546 | 200 µg/ml | $364.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 594 | sc-390789 AF594 | 200 µg/ml | $364.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 647 | sc-390789 AF647 | 200 µg/ml | $364.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 680 | sc-390789 AF680 | 200 µg/ml | $364.00 | |||
Testican-1 Antibody (C-3) Alexa Fluor® 790 | sc-390789 AF790 | 200 µg/ml | $364.00 |