Testican-1 Antibody (A-3): sc-398782

Testican-1 Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects Testican-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Testican-1 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Testican family, also known as the BM-40/SPARC/osteonectin family, consists of highly conserved, extracellular, calcium-binding sulfate proteoglycans that play crucial roles in cellular processes. Testican-1 is predominantly expressed in the thalamus of the brain and shows significant upregulation in activated astroglial cells following neural injuries, such as cerebral strokes. This upregulation mediates neuronal attachment and influences matrix metalloproteinase activation, essential for tissue remodeling and repair. Testican-1 interacts with matrix metalloproteinases, specifically inhibiting pro-MMP-2 activity, thereby regulating extracellular matrix turnover. Expression in joint and growth plate cartilage further underscores Testican-1′s importance in maintaining cartilage integrity and function. Testican-1′s ability to modulate cellular interactions and matrix dynamics makes this protein a key player in both neurobiology and tissue homeostasis, highlighting relevance in research and therapeutic applications.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Testican-1 Antibody (A-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Testican-1 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Testican-1 Antibody (A-3) Specifications

Alternate Product Name: Testican-1

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 161-238

Epitope Target: Testican-1

Epitope Species: human

Product Reactivity/Detection: Testican-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Testican-1 Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Testican-1 antibody is Testican-1 Antibody (C-3): sc-390789.