TDP2 Antibody (H-6): sc-377280

TDP2 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TDP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TDP2 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TDP2 plays a crucial role in the DNA damage response by facilitating the repair of DNA double-strand breaks through its function as a tyrosyl-DNA phosphodiesterase, which removes the 3′ phosphotyrosyl adducts formed during the repair process. This function is vital for maintaining genomic stability, as failure to properly repair DNA can lead to mutations, cancer, and other genetic disorders. TDP2 is predominantly localized in the nucleus, where TDP2 interacts with various proteins involved in DNA repair pathways, underscoring TDP2′s importance in cellular responses to DNA damage. TDP2′s interaction with other proteins, such as Ets-1, highlights TDP2′s regulatory role in transcriptional activity, further emphasizing TDP2′s significance in cellular processes.

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TDP2 Antibody (H-6) References:

1. EAPII interacts with ETS1 and modulates its transcriptional function.  |  Pei, H., et al. 2003. Oncogene. 22: 2699-709. PMID: 12743594
2. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.  |  Xin, JH., et al. 1992. Genes Dev. 6: 481-96. PMID: 1547944
3. Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1.  |  Fisher, CL., et al. 1991. J Immunol. 146: 1743-9. PMID: 1900874
4. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins.  |  Burtis, KC., et al. 1990. Cell. 61: 85-99. PMID: 2107982
5. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.  |  Zeng, Z., et al. 2012. Nucleic Acids Res. 40: 8371-80. PMID: 22740648
6. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.  |  Gómez-Herreros, F., et al. 2014. Nat Genet. 46: 516-21. PMID: 24658003
7. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.  |  Rao, VN., et al. 1989. Science. 244: 66-70. PMID: 2539641
8. Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).  |  Kankanala, J., et al. 2016. J Med Chem. 59: 2734-46. PMID: 26910725
9. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
10. Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux.  |  Komulainen, E., et al. 2019. ACS Chem Biol. 14: 1110-1114. PMID: 31091068
11. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.  |  Rao, VN., et al. 1987. Science. 237: 635-9. PMID: 3299708
12. The erg gene: a human gene related to the ets oncogene.  |  Reddy, ES., et al. 1987. Proc Natl Acad Sci U S A. 84: 6131-5. PMID: 3476934

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TDP2 Antibody (H-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TDP2 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TDP2 Antibody (H-6) Specifications

Alternate Product Name: TDP2

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 63-362

Epitope Target: TDP2

Epitope Species: human

Product Reactivity/Detection: TDP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TDP2 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin