TDAG51 Antibody (RN-6E2): sc-23866

TDAG51 Antibody (RN-6E2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TDAG51 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Anti-TDAG51 antibody (RN-6E2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TDAG51, also known as Pleckstrin Homology Like Domain Family A Member 1, plays a pivotal role in regulating T cell apoptosis, which is crucial for maintaining immune homeostasis and preventing autoimmunity. Located primarily in cytoplasm and nucleus of T cells, TDAG51 is involved in signaling pathways that link T cell receptor stimulation to FAS receptor expression, a key player in apoptotic process. TDAG51 serves as a critical mediator in immune response by restoring activation-induced apoptosis in T cells that have lost FAS expression ability. TDAG51′s role in modulating apoptosis highlights its importance in immuno-surveillance and overall regulation of immune responses, making TDAG51 a valuable target for research in immunology and cancer therapy.

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TDAG51 Antibody (RN-6E2) References:

1. TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo.  |  Rho, J., et al. 2001. Mol Cell Biol. 21: 8365-70. PMID: 11713273
2. Role of perforin in lymphocyte-mediated cytolysis.  |  Yagita, H., et al. 1992. Adv Immunol. 51: 215-42. PMID: 1502975
3. A central role of perforin in cytolysis?  |  Podack, ER., et al. 1991. Annu Rev Immunol. 9: 129-57. PMID: 1910674
4. Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes.  |  Young, JD., et al. 1988. Immunol Rev. 103: 161-202. PMID: 3292393
5. TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.  |  Liu, C., et al. 2022. Inflammation. 45: 1520-1533. PMID: 35175494
6. TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.  |  Wu, X. and Xiao, B. 2023. Balkan Med J. 40: 175-181. PMID: 36960944
7. TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.  |  Park, ES., et al. 2023. EMBO J. 42: e111867. PMID: 37203866
8. Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.  |  Yousof, TR., et al. 2024. J Biol Chem. 300: 105655. PMID: 38237682
9. Mechanism of lymphocyte-mediated cytotoxicity.  |  Henkart, PA. 1985. Annu Rev Immunol. 3: 31-58. PMID: 3904772
10. Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.  |  Hanabuchi, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 4930-4. PMID: 7515183
11. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.  |  Drappa, J., et al. 1993. Proc Natl Acad Sci U S A. 90: 10340-4. PMID: 7694292
12. A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death.  |  Park, CG., et al. 1996. Immunity. 4: 583-91. PMID: 8673705

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TDAG51 Antibody (RN-6E2) has 38 citations in a variety of scientific publications.

Primary antibodies like Anti-TDAG51 Antibody (RN-6E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TDAG51 Antibody (RN-6E2) Specifications

Alternate Product Name: PHLDA1

Product Clone Name: RN-6E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: TDAG51

Epitope Species: human

Product Reactivity/Detection: TDAG51

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 38 citations in various scientific publications

Available Conjugates/Forms for TDAG51 Antibody (RN-6E2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin