TCR V β 16 Antibody (HIS42): sc-59385

TCR V β 16 Antibody (HIS42) is a mouse monoclonal IgG1 antibody that detects T cell receptor V β 16 in mouse and rat samples through immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). TCR V β 16 plays a crucial role in the immune response by recognizing specific foreign antigens, which is essential for the activation and proliferation of T cells. TCR V β 16 is part of the T cell receptor complex, which is vital for T cell development and function. The T cell receptor is composed of two chains, either α and β or γ and δ, with TCR V β 16 specifically contributing to the α/β heterodimer that is predominantly expressed in T cells. TCR V β 16′s ability to recognize a diverse array of antigens is facilitated by the unique structure of its variable region, which undergoes somatic recombination during T cell maturation. This process allows for a vast repertoire of T cell receptors, enabling the immune system to respond effectively to a wide range of pathogens. Understanding the function and specificity of TCR V β 16 is vital for developing targeted immunotherapies and enhancing our knowledge of T cell-mediated immunity.

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TCR V β 16 Antibody (HIS42) References:

1. Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis.  |  Thompson, SD., et al. 1995. J Rheumatol. 22: 1356-64. PMID: 7562772
2. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis: TCR beta-chain-variable-region V beta 8.2-positive T cells are not essential for induction and course of disease.  |  Gold, R., et al. 1995. Proc Natl Acad Sci U S A. 92: 5850-4. PMID: 7597040
3. Preferential distribution of V beta 8.2-positive T cells in the central nervous system of rats with myelin basic protein-induced autoimmune encephalomyelitis.  |  Tsuchida, M., et al. 1993. Eur J Immunol. 23: 2399-406. PMID: 7691605
4. Discrepancy in T cell clonal expansions in synovial fluid and peripheral blood from rheumatoid arthritis patients.  |  Choi, IH., et al. 1995. Yonsei Med J. 36: 68-76. PMID: 7740838
5. Preferential TCR V usage in rat repertoire selection: V alpha 8 imparts both positive thymic selection by and alloreactivity to RT1f.  |  Torres-Nagel, NE., et al. 1994. Int Immunol. 6: 1367-73. PMID: 7819145
6. Selective activation and accumulation of oligoclonal V beta-specific T cells in active pulmonary sarcoidosis.  |  Forman, JD., et al. 1994. J Clin Invest. 94: 1533-42. PMID: 7929830
7. Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.  |  Hingorani, R., et al. 1993. J Immunol. 151: 5762-9. PMID: 8228260
8. T cell receptor V beta gene bias in rheumatoid arthritis.  |  Jenkins, RN., et al. 1993. J Clin Invest. 92: 2688-701. PMID: 8254025
9. Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats.  |  Hanawa, H., et al. 1996. Circ Res. 78: 118-25. PMID: 8603494
10. Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice.  |  Mendel Kerlero de Rosbo, N. and Ben-Nun, A. 1996. Eur J Immunol. 26: 2470-9. PMID: 8898962

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.