TCR Antibody (KJ12-98): sc-65738
- TCR Antibody (KJ12-98) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against T cell hybridoma 3DT-52.5 of mouse origin
- recommended for detection of 3DT-52.5 T-cell receptors of mouse origin by IP and FCM
- also provided azide-free for blocking T cell receptor on the hybridoma 3DT-52.5, sc-65738 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TCR Antibody (KJ12-98). These reagents are now offered in bundles with TCR Antibody (KJ12-98) (see ordering information below).
QUICK LINKS
SEE ALSO...
TCR Antibody (KJ12-98) is a mouse monoclonal IgG2a light chain antibody that detects T cell antigen receptor (TCR) in mouse samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. Anti-TCR antibody (KJ12-98) specifically recognizes TCR, which plays a crucial role in the immune response by enabling T cells to identify and respond to foreign antigens. TCR (KJ12-98) antibody recognizes TCR, a heterodimer composed of either alpha and beta or gamma and delta chains, with the majority of T cells (approximately 95%) expressing the alpha/beta heterodimer. This receptor is essential for T cell activation, as TCR translates the recognition of antigens into intracellular signals that prompt T cells to transition from a dormant state to an activated state, thereby initiating an immune response. TCR is typically expressed alongside CD3 chains and either CD4 or CD8 co-receptors, which are vital for effective signal transduction. CD4, a membrane glycoprotein with four extracellular immunoglobulin-like domains, enhances the interaction between TCR and class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells. This interaction is critical for the activation of T helper cells, which express CD4, and T cytotoxic cells, which express CD8, thereby underscoring TCR′s importance in orchestrating adaptive immunity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCR Antibody (KJ12-98) References:
- Searching for significance in TCR-cytoskeleton interactions. | Caplan, S. and Baniyash, M. 2000. Immunol Today. 21: 223-8. PMID: 10782053
- Deciphering the pathway from the TCR to NF-kappaB. | Weil, R. and Israël, A. 2006. Cell Death Differ. 13: 826-33. PMID: 16439988
- T cell receptor (TcR) beta chain transgenic mice: studies on allelic exclusion and on the TcR+ gamma/delta population. | Pircher, H., et al. 1990. Eur J Immunol. 20: 417-24. PMID: 1968840
- Serine-threonine kinases in TCR signaling. | Navarro, MN. and Cantrell, DA. 2014. Nat Immunol. 15: 808-14. PMID: 25137455
- T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. | Sancho, J., et al. 1989. J Biol Chem. 264: 20760-9. PMID: 2531145
- CD3ε recruits Numb to promote TCR degradation. | Martin-Blanco, N., et al. 2016. Int Immunol. 28: 127-37. PMID: 26507128
- LAG3 disrupts the TCR signal by local acidification. | Hivroz, C. 2022. Nat Immunol. 23: 649-651. PMID: 35477982
- Increased TCR signaling in regulatory T cells is disengaged from TCR affinity. | Jing, Y., et al. 2023. bioRxiv.. PMID: 36711832
- Assessing TCR identity, knock-in efficiency, and potency for individualized TCR-T cell therapy. | Camperi, J., et al. 2023. J Immunol Methods. 517: 113491. PMID: 37187316
- TCR gene polymorphisms and autoimmune disease. | Kay, RA. 1996. Eur J Immunogenet. 23: 161-77. PMID: 8732480
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR Antibody (KJ12-98) | sc-65738 | 200 µg/ml | $322.00 | |||
TCR Antibody (KJ12-98): m-IgG Fc BP-HRP Bundle | sc-537179 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCR Antibody (KJ12-98): m-IgGκ BP-HRP Bundle | sc-534380 | 200 µg Ab; 40 µg BP | $361.00 | |||
TCR Antibody (KJ12-98) L | sc-65738 L | 200 µg/0.1 ml | $322.00 |