TCR α/β Antibody (R73): sc-19600
- TCR α/β Antibody (R73) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- recommended for detection of TCR α/β of mouse and rat origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for in vitro stimulation of α/β TCR-expressing T cells, in vivo depletion and/or suppression of α/β TCR-expressing T cells, sc-19600 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TCR α/β Antibody (R73) for WB and IHC(P) applications. These reagents are now offered in bundles with TCR α/β Antibody (R73) (see ordering information below).
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TCR α/β Antibody (R73) is a mouse monoclonal IgG1 antibody that detects T cell antigen receptor (TCR) in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-TCR α/β antibody (R73) specifically recognizes TCR, which plays a crucial role in the immune response by enabling T cells to identify and respond to foreign antigens. TCR α/β (R73) monoclonal antibody recognizes a heterodimer composed of either alpha and beta or gamma and delta chains, with the alpha/beta form being predominant in the majority of circulating T cells. This receptor is essential for T cell activation, as TCR translates the recognition of antigens into intracellular signals that prompt T cells to transition from a dormant state to an activated state, thereby initiating an immune response. TCR′s interaction with antigen-presenting cells is further enhanced by the presence of CD3 chains and co-receptors such as CD4 or CD8, which are critical for effective signal transduction. TCR α/β (R73) antibody is particularly valuable for researchers studying T cell biology, immune responses, and the mechanisms of T cell activation, providing insights into both basic immunology and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TCR α/β Antibody (R73) References:
- Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines. | Matsumoto, Y. 2000. J Neuroimmunol. 110: 1-12. PMID: 11024529
- T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice. | Olasz, K., et al. 2012. Clin Exp Immunol. 167: 346-55. PMID: 22236012
- Mechanisms of localized activation of the T cell antigen receptor inside clusters. | Neve-Oz, Y., et al. 2015. Biochim Biophys Acta. 1853: 810-21. PMID: 25300584
- Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells. | Bajwa, G., et al. 2020. J Immunother Cancer. 8: PMID: 33148692
- Assessing TCR identity, knock-in efficiency, and potency for individualized TCR-T cell therapy. | Camperi, J., et al. 2023. J Immunol Methods. 517: 113491. PMID: 37187316
- Ontogeny of the T-cell antigen receptor within the thymus. | Snodgrass, HR., et al. Nature. 313: 592-5. PMID: 3871511
- scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC. | Peng, Q., et al. 2024. J Immunother Cancer. 12: PMID: 39237261
- The murine T cell antigen receptor and associated structures. | Allison, JP., et al. 1984. Immunol Rev. 81: 145-60. PMID: 6210241
- The structure of the T cell antigen receptor. | Bentley, GA. and Mariuzza, RA. 1996. Annu Rev Immunol. 14: 563-90. PMID: 8717525
- T cell receptor (TCR) repertoire in alloimmune responses. | Finn, OJ., et al. 1996. Int Rev Immunol. 13: 187-207. PMID: 8782741
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR α/β Antibody (R73) | sc-19600 | 200 µg/ml | $316.00 | |||
TCR α/β Antibody (R73): m-IgG Fc BP-HRP Bundle | sc-536620 | 200 µg Ab; 10 µg BP | $354.00 | |||
TCR α/β Antibody (R73): m-IgGκ BP-HRP Bundle | sc-533777 | 200 µg Ab; 40 µg BP | $354.00 | |||
TCR α/β Antibody (R73) FITC | sc-19600 FITC | 200 µg/ml | $330.00 | |||
TCR α/β Antibody (R73) L | sc-19600 L | 200 µg/0.1 ml | $316.00 | |||
TCR α/β Antibody (R73) PE | sc-19600 PE | 200 µg/ml | $343.00 |