TCP-1 ε Antibody (D-6): sc-374554

TCP-1 ε Antibody (D-6) is a mouse monoclonal IgG2a antibody that detects TCP-1 ε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 ε is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and TCP-1 ε plays a significant role in ensuring that these proteins achieve their functional conformations. TCP-1 ε functions extend beyond protein folding to cellular processes such as cytoskeletal organization and cellular signaling, which are vital for maintaining cellular integrity and function. Abnormalities in TCP-1 ε expression or function can lead to various diseases, including neurodegenerative disorders, highlighting the relevance of TCP-1 ε in both health and disease. Anti-TCP-1 ε antibody (D-6) serves as an invaluable tool for researchers studying protein folding dynamics and chaperonin function in various biological contexts.

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TCP-1 ε Antibody (D-6) References:

1. Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.  |  Ooe, A., et al. 2007. Breast Cancer Res Treat. 101: 305-15. PMID: 16821082
2. A human CCT5 gene mutation causing distal neuropathy impairs hexadecamer assembly in an archaeal model.  |  Min, W., et al. 2014. Sci Rep. 4: 6688. PMID: 25345891
3. Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog.  |  Spigolon, D., et al. 2017. Biochem Biophys Rep. 12: 66-71. PMID: 29552646
4. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis.  |  Wang, Q., et al. 2019. Vet Microbiol. 235: 151-163. PMID: 31282373
5. CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway.  |  Li, Y., et al. 2022. Br J Cancer. 126: 1684-1694. PMID: 35194191
6. Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies.  |  Scalia, F., et al. 2023. Int J Mol Sci. 24: PMID: 36768350
7. Maize tubulin folding cofactor B is required for cell division and cell growth through modulating microtubule homeostasis.  |  Zhou, Q., et al. 2023. New Phytol. 239: 1707-1722. PMID: 36843261
8. Histopathology of Skeletal Muscle in a Distal Motor Neuropathy Associated with a Mutant CCT5 Subunit: Clues for Future Developments to Improve Differential Diagnosis and Personalized Therapy.  |  Scalia, F., et al. 2023. Biology (Basel). 12: PMID: 37237456
9. Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons.  |  Righetto, GL., et al. 2024. PNAS Nexus. 3: pgae153. PMID: 38665159
10. Epsilon subunit of T-complex protein-1 from Leishmania donovani: A tetrameric chaperonin.  |  Anand, A., et al. 2024. Gene. 926: 148637. PMID: 38844270

The preferred TCP-1 ε antibody is TCP-1 ε Antibody (G-3): sc-376188.