TCF-3 Antibody (F-5): sc-398640
- TCF-3 Antibody (F-5) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against amino acids 421-575 of TCF-3 of mouse origin
- recommended for detection of TCF-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-398640 X, 200 µg/0.1 ml)
- See TCF-3 (E-2): sc-166411 for TCF-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TCF-3 Antibody (F-5) for WB applications. These reagents are now offered in bundles with TCF-3 Antibody (F-5) (see ordering information below).
TCF-3 Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects TCF-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCF-3, a member of the TCF/LEF family of transcription factors, plays a crucial role in regulating gene expression during developmental processes, particularly in the central nervous system and lymphoid cell development. TCF-3 is primarily located in the nucleus, where TCF-3 forms complexes with β-catenin, a key mediator of the Wnt signaling pathway. This interaction is vital for the transcriptional activation of Wnt target genes, which are essential for various cellular functions, including cell proliferation and differentiation. Proper localization of TCF-3 within the nucleus ensures effective regulation of these processes, and any dysregulation can lead to developmental abnormalities or contribute to oncogenesis. Notably, mutations in the adenomatous polyposis coli (APC) gene can disrupt the regulatory mechanisms governing TCF-3 activity, leading to an accumulation of β-catenin and aberrant activation of TCF target genes, which is often observed in colorectal cancer. With insights into these critical pathways, anti-TCF-3 antibody (F-5) is an invaluable tool for researchers studying developmental biology and cancer.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCF-3 Antibody (F-5) | sc-398640 | 200 µg/ml | $322.00 | |||
TCF-3 Antibody (F-5): m-IgG Fc BP-HRP Bundle | sc-538487 | 200 µg Ab; 10 µg BP | $361.00 | |||
TCF-3 Antibody (F-5): m-IgGκ BP-HRP Bundle | sc-536111 | 200 µg Ab; 40 µg BP | $361.00 | |||
TCF-3 Antibody (F-5) X | sc-398640 X | 200 µg/0.1 ml | $322.00 |