TCF-3 Antibody (F-5): sc-398640

TCF-3 Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects TCF-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCF-3, a member of the TCF/LEF family of transcription factors, plays a crucial role in regulating gene expression during developmental processes, particularly in the central nervous system and lymphoid cell development. TCF-3 is primarily located in the nucleus, where TCF-3 forms complexes with β-catenin, a key mediator of the Wnt signaling pathway. This interaction is vital for the transcriptional activation of Wnt target genes, which are essential for various cellular functions, including cell proliferation and differentiation. Proper localization of TCF-3 within the nucleus ensures effective regulation of these processes, and any dysregulation can lead to developmental abnormalities or contribute to oncogenesis. Notably, mutations in the adenomatous polyposis coli (APC) gene can disrupt the regulatory mechanisms governing TCF-3 activity, leading to an accumulation of β-catenin and aberrant activation of TCF target genes, which is often observed in colorectal cancer. With insights into these critical pathways, anti-TCF-3 antibody (F-5) is an invaluable tool for researchers studying developmental biology and cancer.

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TCF-3 Antibody (F-5) References:

1. Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation.  |  Sagara, N. and Katoh, M. 2000. Cancer Res. 60: 5959-62. PMID: 11085512
2. Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).  |  Tejpar, S., et al. 2001. Br J Cancer. 85: 98-101. PMID: 11437409
3. Lef-1 and Tcf-3 transcription factors mediate tissue-specific Wnt signaling during Xenopus development.  |  Roël, G., et al. 2002. Curr Biol. 12: 1941-5. PMID: 12445388
4. Analysis of the Tcf-3 promoter during early development of Xenopus.  |  Spieker, N., et al. 2004. Dev Dyn. 231: 510-7. PMID: 15376330
5. TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers.  |  Balaz, P., et al. 2010. Int J Colorectal Dis. 25: 931-9. PMID: 20532534
6. miR-24 affects hair follicle morphogenesis targeting Tcf-3.  |  Amelio, I., et al. 2013. Cell Death Dis. 4: e922. PMID: 24232098
7. Solid pseudopapillary neoplasm expresses inhibin-α and Tcf-3.  |  Shirai Et Al,., et al. 2017. Pathol Int. 67: 228-229. PMID: 28213917
8. TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFβ signaling in gastroenteropancreatic neuroendocrine neoplasms.  |  Xue, J., et al. 2021. Aging (Albany NY). 13: 14065-14077. PMID: 34037532
9. Retraction: RNAi-mediated TCF-3 gene silencing inhibits proliferation of Eca-109 esophageal cancer cells by inducing apoptosis.  |  . 2021. Biosci Rep. 41: PMID: 34515294
10. From agammaglobulinemia to neutropenia: 'The TCF-3 has different clinical presentations'.  |  Kose, H., et al. 2024. Scand J Immunol. 100: e13423. PMID: 39523462

The preferred TCF7L2/TCF4 antibody is TCF7L2/TCF4 Antibody (D-4): sc-166699.