TBCC Antibody (G-10): sc-390635
- TBCC Antibody (G-10) is a mouse monoclonal IgG1 κ TBCC antibody provided at 200 µg/ml
- raised against amino acids 258-346 mapping at the C-terminus of TBCC of human origin
- TBCC Antibody (G-10) is recommended for detection of TBCC of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TBCC Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TBCC Antibody (G-10) for WB and IHC(P) applications. These reagents are now offered in bundles with TBCC Antibody (G-10) (see ordering information below).
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TBCC Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBCC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TBCC (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBCC protein, also known as tubulin-specific chaperone C, plays a crucial role in proper folding and assembly of tubulin, which is essential for microtubule formation, the primary components of the cytoskeletal network. Microtubules are vital for numerous cellular processes, including maintaining cell shape, enabling intracellular transport, and facilitating cell division. TBCC′s function in promoting tubulin polypeptide release into their native state is particularly important, as disruption in this process can lead to cytoskeletal abnormalities and has been linked to various diseases, including X-linked retinitis pigmentosa, where mutations in related proteins result in photoreceptor cell degeneration. Using anti-TBCC antibody (G-10) in research can provide valuable insights into microtubule dynamics and their implications in cellular health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBCC Antibody (G-10) References:
- Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. | Bartolini, F., et al. 2002. J Biol Chem. 277: 14629-34. PMID: 11847227
- Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. | Grynberg, M., et al. 2003. BMC Bioinformatics. 4: 46. PMID: 14536023
- Cryptic out-of-frame translational initiation of TBCE rescues tubulin formation in compound heterozygous HRD. | Tian, G., et al. 2006. Proc Natl Acad Sci U S A. 103: 13491-6. PMID: 16938882
- Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. | Kortazar, D., et al. 2007. Exp Cell Res. 313: 425-36. PMID: 17184771
- Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin ring complex at centrosomes and organization of the mitotic spindle. | Cunningham, LA. and Kahn, RA. 2008. J Biol Chem. 283: 7155-65. PMID: 18171676
- Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells. | Hage-Sleiman, R., et al. 2010. BMC Cancer. 10: 135. PMID: 20384997
- Pathway leading to correctly folded beta-tubulin. | Tian, G., et al. 1996. Cell. 86: 287-96. PMID: 8706133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBCC Antibody (G-10) | sc-390635 | 200 µg/ml | $322.00 | |||
TBCC Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-530209 | 200 µg Ab; 10 µg BP | $361.00 | |||
TBCC Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-523612 | 200 µg Ab, 40 µg BP | $361.00 | |||
TBCC Antibody (G-10): m-IgG1 BP-HRP Bundle | sc-543931 | 200 µg Ab; 20 µg BP | $361.00 | |||
TBCC Antibody (G-10) AC | sc-390635 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBCC Antibody (G-10) HRP | sc-390635 HRP | 200 µg/ml | $322.00 | |||
TBCC Antibody (G-10) FITC | sc-390635 FITC | 200 µg/ml | $336.00 | |||
TBCC Antibody (G-10) PE | sc-390635 PE | 200 µg/ml | $349.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 488 | sc-390635 AF488 | 200 µg/ml | $364.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 546 | sc-390635 AF546 | 200 µg/ml | $364.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 594 | sc-390635 AF594 | 200 µg/ml | $364.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 647 | sc-390635 AF647 | 200 µg/ml | $364.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 680 | sc-390635 AF680 | 200 µg/ml | $364.00 | |||
TBCC Antibody (G-10) Alexa Fluor® 790 | sc-390635 AF790 | 200 µg/ml | $364.00 |