TBC1D2B Antibody (E-8): sc-398906
- TBC1D2B Antibody (E-8) is a mouse monoclonal IgG1 κ TBC1D2B antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 591-610 within an internal region of TBC1D2B of human origin
- TBC1D2B Antibody (E-8) is recommended for detection of TBC1D2B of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TBC1D2B Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TBC1D2B (E-8): sc-398906.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TBC1D2B Antibody (E-8) for WB applications. These reagents are now offered in bundles with TBC1D2B Antibody (E-8) (see ordering information below).
TBC1D2B Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBC1D2B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBC1D2B Antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D2B consists of 963 amino acids and plays a crucial role in regulating GTPase activity, specifically acting as a GTPase-activating protein (GAP) that enhances intrinsic GTP hydrolysis rate of Ras-related proteins, thereby downregulating their active forms. This function is vital for maintaining cellular signaling pathways and ensuring proper cellular responses to external stimuli. TBC1D2B contains a pleckstrin homology (PH) domain and a Rab-GAP TBC domain, and exists in three alternatively spliced isoforms, which may have distinct regulatory roles in different cellular contexts. The gene encoding TBC1D2B is located on human chromosome 15, a region associated with several genetic disorders, including Angelman syndrome and Prader-Willi syndrome, highlighting TBC1D2B′s importance in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBC1D2B Antibody (E-8) References:
- A germline-specific class of small RNAs binds mammalian Piwi proteins. | Girard, A., et al. 2006. Nature. 442: 199-202. PMID: 16751776
- Diagnosis and management of patients with Marfan syndrome. | Midla, GS. 2008. JAAPA. 21: 21-5. PMID: 18323350
- Angelman syndrome: current understanding and research prospects. | Dan, B. 2009. Epilepsia. 50: 2331-9. PMID: 19874386
- The C15orf2 gene in the Prader-Willi syndrome region is subject to genomic imprinting and positive selection. | Wawrzik, M., et al. 2010. Neurogenetics. 11: 153-61. PMID: 20020165
- Tyrosinemia type 1 and Angelman syndrome due to paternal uniparental isodisomy 15. | Ferrer-Bolufer, I., et al. 2009. J Inherit Metab Dis. 32 Suppl 1: S349-53. PMID: 20033293
- Network organization of the human autophagy system. | Behrends, C., et al. 2010. Nature. 466: 68-76. PMID: 20562859
- Neuropsychiatric aspects of adult-onset Tay-Sachs disease: two case reports with several new findings. | Hurowitz, GI., et al. 1993. J Neuropsychiatry Clin Neurosci. 5: 30-6. PMID: 8428133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBC1D2B Antibody (E-8) | sc-398906 | 200 µg/ml | $316.00 | |||
TBC1D2B Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-530961 | 200 µg Ab; 10 µg BP | $354.00 | |||
TBC1D2B Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-524528 | 200 µg Ab, 40 µg BP | $354.00 | |||
TBC1D2B Antibody (E-8) AC | sc-398906 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TBC1D2B Antibody (E-8) HRP | sc-398906 HRP | 200 µg/ml | $316.00 | |||
TBC1D2B Antibody (E-8) FITC | sc-398906 FITC | 200 µg/ml | $330.00 | |||
TBC1D2B Antibody (E-8) PE | sc-398906 PE | 200 µg/ml | $343.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 488 | sc-398906 AF488 | 200 µg/ml | $357.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 546 | sc-398906 AF546 | 200 µg/ml | $357.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 594 | sc-398906 AF594 | 200 µg/ml | $357.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 647 | sc-398906 AF647 | 200 µg/ml | $357.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 680 | sc-398906 AF680 | 200 µg/ml | $357.00 | |||
TBC1D2B Antibody (E-8) Alexa Fluor® 790 | sc-398906 AF790 | 200 µg/ml | $357.00 | |||
TBC1D2B (E-8) Neutralizing Peptide | sc-398906 P | 100 µg/0.5 ml | $68.00 |