TBC1D10C Antibody (G-5): sc-393379
- TBC1D10C Antibody (G-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 26-138 mapping near the N-terminus of TBC1D10C of human origin
- TBC1D10C Antibody (G-5) is recommended for detection of TBC1D10C of human origin by WB, IP, IF and ELISA
- Anti-TBC1D10C Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TBC1D10C Antibody (G-5) for WB applications. These reagents are now offered in bundles with TBC1D10C Antibody (G-5) (see ordering information below).
TBC1D10C Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBC1D10C of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-TBC1D10C antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D10C, also known as Carabin, is a 446 amino acid protein characterized by the presence of a Rab-GAP TBC domain, which plays a crucial role in regulating cellular signaling pathways. TBC1D10C is predominantly expressed in the spleen and peripheral blood leukocytes, where TBC1D10C functions as a GTPase-activating protein that enhances the hydrolysis of GTP on Ras-related proteins, thereby downregulating their active forms. TBC1D10C interaction with protein phosphatase 2B (PP2B) proteins is particularly significant, as TBC1D10C serves as a negative feedback mechanism that mediates crosstalk between Ras signaling and PP2B activity, which is essential for maintaining cellular homeostasis and regulating various physiological processes. TBC1D10C gene is located on human chromosome 11, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting TBC1D10C importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBC1D10C Antibody (G-5) References:
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
- The 11q terminal deletion disorder: a prospective study of 110 cases. | Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
- Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome. | Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
- Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. | Pan, F., et al. 2007. Nature. 445: 433-6. PMID: 17230191
- Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. | Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
- The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. | Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
- Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. | Patino-Lopez, G., et al. 2008. J Biol Chem. 283: 18323-30. PMID: 18450757
- A model for p53-induced apoptosis. | Polyak, K., et al. 1997. Nature. 389: 300-5. PMID: 9305847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBC1D10C Antibody (G-5) | sc-393379 | 200 µg/ml | $316.00 | |||
TBC1D10C Antibody (G-5): m-IgGκ BP-HRP Bundle | sc-523921 | 200 µg Ab, 40 µg BP | $354.00 | |||
TBC1D10C Antibody (G-5): m-IgG1 BP-HRP Bundle | sc-533625 | 200 µg Ab; 20 µg BP | $354.00 | |||
TBC1D10C Antibody (G-5) AC | sc-393379 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TBC1D10C Antibody (G-5) HRP | sc-393379 HRP | 200 µg/ml | $316.00 | |||
TBC1D10C Antibody (G-5) FITC | sc-393379 FITC | 200 µg/ml | $330.00 | |||
TBC1D10C Antibody (G-5) PE | sc-393379 PE | 200 µg/ml | $343.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 488 | sc-393379 AF488 | 200 µg/ml | $357.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 546 | sc-393379 AF546 | 200 µg/ml | $357.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 594 | sc-393379 AF594 | 200 µg/ml | $357.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 647 | sc-393379 AF647 | 200 µg/ml | $357.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 680 | sc-393379 AF680 | 200 µg/ml | $357.00 | |||
TBC1D10C Antibody (G-5) Alexa Fluor® 790 | sc-393379 AF790 | 200 µg/ml | $357.00 |