Tau Antibody (Tau-13): sc-21796

Tau Antibody (Tau-13) is a mouse monoclonal IgG1 kappa light chain antibody specifically developed to recognize human recombinant Tau protein. Anti-Tau antibody (Tau-13) detects all Tau isoforms from mouse, rat, and human sources, making it suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Tau, also known as MAPT (microtubule-associated protein tau), or TAU, is a 758 amino acid protein integral to the stabilization and assembly of microtubules in neuronal cells. Located primarily in the cytoplasm, cytoskeleton, and cell membrane, Tau contains four Tau/MAP repeats that facilitate binding to microtubules, thereby maintaining neuronal polarity and supporting cytoskeletal plasticity. Expressed predominantly in neuronal tissue, Tau exists in multiple alternatively spliced isoforms that are crucial for the dynamic restructuring of the cytoskeleton essential for proper neuronal function. Tau undergoes various post-translational modifications, including phosphorylation, polyubiquitination, and glycation, which regulate activity and degradation processes. Dysregulation or mutations in the Tau gene are associated with several neurodegenerative disorders, such as Alzheimer′s disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), highlighting Tau′s critical role in neuronal health. Tau monoclonal antibody (Tau-13) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing researchers with flexible options for diverse experimental setups.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Tau Antibody (Tau-13) References:

1. Tau fibrillogenesis.  |  Chaudhary, N. and Nagaraj, R. 2012. Subcell Biochem. 65: 75-90. PMID: 23225000
2. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease.  |  Goedert, M., et al. 1989. Neuron. 3: 519-26. PMID: 2484340
3. Role of microtubule-associated protein tau phosphorylation in Alzheimer's disease.  |  Ma, RH., et al. 2017. J Huazhong Univ Sci Technolog Med Sci. 37: 307-312. PMID: 28585125
4. Synaptic Localisation of Tau.  |  Hanger, DP., et al. 2019. Adv Exp Med Biol. 1184: 105-112. PMID: 32096032
5. The Role of Tau in the Post-synapse.  |  Regan, P. and Cho, K. 2019. Adv Exp Med Biol. 1184: 113-121. PMID: 32096033
6. Tau Oligomers.  |  Maeda, S. and Takashima, A. 2019. Adv Exp Med Biol. 1184: 373-380. PMID: 32096050
7. Tau internalization: A complex step in tau propagation.  |  Zhao, J., et al. 2021. Ageing Res Rev. 67: 101272. PMID: 33571704
8. The Fate of Tau Aggregates Between Clearance and Transmission.  |  Seitkazina, A., et al. 2022. Front Aging Neurosci. 14: 932541. PMID: 35923541
9. Tau: More than a microtubule-binding protein in neurons.  |  Alonso, ADC., et al. 2024. Cytoskeleton (Hoboken). 81: 71-77. PMID: 37819542
10. Nuclear face of Tau: an inside player in neurodegeneration.  |  Younas, N., et al. 2023. Acta Neuropathol Commun. 11: 196. PMID: 38087392

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tau Antibody (Tau-13) has 34 citations in a variety of scientific publications.

Primary antibodies like Anti-Tau Antibody (Tau-13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tau Antibody (Tau-13) Specifications

Alternate Product Name: MAPT

Product Clone Name: Tau-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Tau

Epitope Species: human

Product Reactivity/Detection: all Tau isoforms

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 34 citations in various scientific publications

Available Conjugates/Forms for Tau Antibody (Tau-13): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Tau antibody is Tau Antibody (Tau 46): sc-32274.