Tau Antibody (Tau-13): sc-21796
- Tau Antibody (Tau-13) is a mouse monoclonal IgG1 κ, cited in 34 publications, provided at 200 µg/ml
- raised against human recombinant Tau
- Anti-Tau Antibody (Tau-13) is recommended for detection of all Tau isoforms of mouse, rat and human origin by WB, IP, IF and IHC(P); not inhibited by Tau phosphorylation
- Anti-Tau Antibody (Tau-13) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to biotin for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Tau Antibody (Tau-13) for WB and IHC(P) applications. These reagents are now offered in bundles with Tau Antibody (Tau-13) (see ordering information below).
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Tau Antibody (Tau-13) is a mouse monoclonal IgG1 kappa light chain antibody specifically developed to recognize human recombinant Tau protein. Anti-Tau antibody (Tau-13) detects all Tau isoforms from mouse, rat, and human sources, making it suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Tau, also known as MAPT (microtubule-associated protein tau), or TAU, is a 758 amino acid protein integral to the stabilization and assembly of microtubules in neuronal cells. Located primarily in the cytoplasm, cytoskeleton, and cell membrane, Tau contains four Tau/MAP repeats that facilitate binding to microtubules, thereby maintaining neuronal polarity and supporting cytoskeletal plasticity. Expressed predominantly in neuronal tissue, Tau exists in multiple alternatively spliced isoforms that are crucial for the dynamic restructuring of the cytoskeleton essential for proper neuronal function. Tau undergoes various post-translational modifications, including phosphorylation, polyubiquitination, and glycation, which regulate activity and degradation processes. Dysregulation or mutations in the Tau gene are associated with several neurodegenerative disorders, such as Alzheimer′s disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), highlighting Tau′s critical role in neuronal health. Tau monoclonal antibody (Tau-13) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, providing researchers with flexible options for diverse experimental setups.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tau Antibody (Tau-13) References:
- Tau fibrillogenesis. | Chaudhary, N. and Nagaraj, R. 2012. Subcell Biochem. 65: 75-90. PMID: 23225000
- Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. | Goedert, M., et al. 1989. Neuron. 3: 519-26. PMID: 2484340
- Role of microtubule-associated protein tau phosphorylation in Alzheimer's disease. | Ma, RH., et al. 2017. J Huazhong Univ Sci Technolog Med Sci. 37: 307-312. PMID: 28585125
- Synaptic Localisation of Tau. | Hanger, DP., et al. 2019. Adv Exp Med Biol. 1184: 105-112. PMID: 32096032
- The Role of Tau in the Post-synapse. | Regan, P. and Cho, K. 2019. Adv Exp Med Biol. 1184: 113-121. PMID: 32096033
- Tau Oligomers. | Maeda, S. and Takashima, A. 2019. Adv Exp Med Biol. 1184: 373-380. PMID: 32096050
- Tau internalization: A complex step in tau propagation. | Zhao, J., et al. 2021. Ageing Res Rev. 67: 101272. PMID: 33571704
- The Fate of Tau Aggregates Between Clearance and Transmission. | Seitkazina, A., et al. 2022. Front Aging Neurosci. 14: 932541. PMID: 35923541
- Tau: More than a microtubule-binding protein in neurons. | Alonso, ADC., et al. 2024. Cytoskeleton (Hoboken). 81: 71-77. PMID: 37819542
- Nuclear face of Tau: an inside player in neurodegeneration. | Younas, N., et al. 2023. Acta Neuropathol Commun. 11: 196. PMID: 38087392
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tau Antibody (Tau-13) | sc-21796 | 200 µg/ml | $322.00 | |||
Tau Antibody (Tau-13): m-IgG Fc BP-HRP Bundle | sc-528371 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tau Antibody (Tau-13): m-IgGκ BP-HRP Bundle | sc-520733 | 200 µg Ab, 40 µg BP | $361.00 | |||
Tau Antibody (Tau-13): m-IgG1 BP-HRP Bundle | sc-542899 | 200 µg Ab; 20 µg BP | $361.00 | |||
Tau Antibody (Tau-13) AC | sc-21796 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Tau Antibody (Tau-13) HRP | sc-21796 HRP | 200 µg/ml | $322.00 | |||
Tau Antibody (Tau-13) FITC | sc-21796 FITC | 200 µg/ml | $336.00 | |||
Tau Antibody (Tau-13) PE | sc-21796 PE | 200 µg/ml | $349.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 488 | sc-21796 AF488 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 546 | sc-21796 AF546 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 594 | sc-21796 AF594 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 647 | sc-21796 AF647 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 680 | sc-21796 AF680 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) Alexa Fluor® 790 | sc-21796 AF790 | 200 µg/ml | $364.00 | |||
Tau Antibody (Tau-13) B | sc-21796 B | 200 µg/ml | $326.00 |