Taspase 1 Antibody (F-7): sc-514676

Taspase 1 Antibody (F-7) is a mouse monoclonal IgG2b antibody that detects Taspase 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Taspase 1 is a crucial endopeptidase composed of 420 amino acids, known for cleaving specific substrates at aspartate residues, which is essential for processing mixed-lineage leukemia (MLL) proteins and the subsequent correct expression of the Hox A gene cluster. Taspase 1 undergoes autoproteolytic processing post-translation, resulting in the formation of two subunits, alpha and beta, that reassemble into a multimeric structure necessary for enzymatic activity. This structural integrity is vital, as any disruption can lead to aberrant gene expression and has been implicated in various hematological malignancies. The gene encoding Taspase 1 is located on human chromosome 20, which harbors over 600 genes associated with several serious conditions, including Creutzfeldt-Jakob disease and amyotrophic lateral sclerosis. Anti-Taspase 1 antibody (F-7) serves as an invaluable tool for researchers studying the molecular mechanisms underlying these diseases and Taspase 1′s role in cellular processes.

The preferred Taspase 1 antibody is Taspase 1 Antibody (D-6): sc-514677.