TARDBP Antibody (41-7.1): sc-100871

TARDBP Antibody (41-7.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects TARDBP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TARDBP antibody (41-7.1) is available in a non-conjugated form, providing flexibility for various experimental needs. TARDBP, also known as TDP-43, is a crucial nuclear protein characterized by two RNA recognition motif (RRM) domains, which facilitate RNA processing and regulation. TARDBP is ubiquitously expressed, with highest concentrations found in placenta, lung, pancreas, spleen, and genital tract, highlighting importance in diverse biological processes. TARDBP monoclonal antibody (41-7.1) recognizes a protein involved in splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, acting as a negative regulator of splicing activity. Additionally, TARDBP binds to TAR DNA sequence motifs of HIV, functioning as a transcriptional repressor that inhibits HIV-1 transcription, thereby playing a role in viral regulation. TARDBP (41-7.1) antibody targets a major component of ubiquitin-positive inclusion bodies, which are associated with various neurodegenerative diseases, suggesting potential involvement in disease pathogenesis. Multiple isoforms of TARDBP due to alternative splicing further underscore functional diversity and relevance in cellular processes.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TARDBP Antibody (41-7.1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-TARDBP Antibody (41-7.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TARDBP Antibody (41-7.1) Specifications

Alternate Product Name: TARDBP

Product Clone Name: 41-7.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-261

Epitope Target: TARDBP

Epitope Species: human

Product Reactivity/Detection: TARDBP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for TARDBP Antibody (41-7.1): N/A

The preferred TARDBP antibody is TARDBP Antibody (E-10): sc-376311.