taperin Antibody (H-4): sc-515824
- taperin Antibody (H-4) is a mouse monoclonal IgG1 κ taperin antibody provided at 200 µg/ml
- raised against amino acids 421-529 mapping within an internal region of taperin of human origin
- taperin Antibody (H-4) is recommended for detection of taperin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-taperin Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for taperin Antibody (H-4) for WB applications. These reagents are now offered in bundles with taperin Antibody (H-4) (see ordering information below).
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Taperin Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects taperin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-taperin antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Taperin (TPRN) is a 711 amino acid sensory epithelial protein that plays a crucial role in the structure and function of hair cell stereocilia, where taperin is predominantly localized at the taper regions. This localization is vital for maintaining the integrity and functionality of the auditory system, as defects in taperin can lead to autosomal recessive deafness type 79 (DFNB79), characterized by progressive hearing loss and eventual profound deafness. The gene encoding taperin spans 9,689 bases and is located on human chromosome 9q34.3, a region that houses over 900 genes and is implicated in various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia. Notably, chromosome 9 also contains the largest cluster of interferon family genes, highlighting its significance in immune response regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
taperin Antibody (H-4) References:
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. | Gold-von Simson, G., et al. 2009. Pediatr Res. 65: 341-6. PMID: 19033881
- Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells. | Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
- DFNB79: reincarnation of a nonsyndromic deafness locus on chromosome 9q34.3. | Khan, SY., et al. 2010. Eur J Hum Genet. 18: 125-9. PMID: 19603065
- Neuroimaging supports central pathology in familial dysautonomia. | Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
- Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss. | Li, Y., et al. 2010. Am J Hum Genet. 86: 479-84. PMID: 20170898
- Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. | Rehman, AU., et al. 2010. Am J Hum Genet. 86: 378-88. PMID: 20170899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
taperin Antibody (H-4) | sc-515824 | 200 µg/ml | $322.00 | |||
taperin Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-531528 | 200 µg Ab; 10 µg BP | $361.00 | |||
taperin Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-525239 | 200 µg Ab, 40 µg BP | $361.00 | |||
taperin Antibody (H-4): m-IgG1 BP-HRP Bundle | sc-544608 | 200 µg Ab; 20 µg BP | $361.00 | |||
taperin Antibody (H-4) AC | sc-515824 AC | 500 µg/ml, 25% agarose | $424.00 | |||
taperin Antibody (H-4) HRP | sc-515824 HRP | 200 µg/ml | $322.00 | |||
taperin Antibody (H-4) FITC | sc-515824 FITC | 200 µg/ml | $336.00 | |||
taperin Antibody (H-4) PE | sc-515824 PE | 200 µg/ml | $349.00 | |||
taperin Antibody (H-4) Alexa Fluor® 488 | sc-515824 AF488 | 200 µg/ml | $364.00 | |||
taperin Antibody (H-4) Alexa Fluor® 546 | sc-515824 AF546 | 200 µg/ml | $364.00 | |||
taperin Antibody (H-4) Alexa Fluor® 594 | sc-515824 AF594 | 200 µg/ml | $364.00 | |||
taperin Antibody (H-4) Alexa Fluor® 647 | sc-515824 AF647 | 200 µg/ml | $364.00 | |||
taperin Antibody (H-4) Alexa Fluor® 680 | sc-515824 AF680 | 200 µg/ml | $364.00 | |||
taperin Antibody (H-4) Alexa Fluor® 790 | sc-515824 AF790 | 200 µg/ml | $364.00 |