Tak1 Antibody (C-9): sc-7967

Tak1 Antibody (C-9) is a mouse monoclonal IgG2a kappa kappa light chain antibody raised against amino acids 1-579 of mouse Tak1 (TGFβ-activated kinase 1), also known as MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7). Tak1 monoclonal antibody (C-9) detects Tak1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tak1 is a serine/threonine kinase that plays a pivotal role in mediating cellular responses to cytokines like TGFβ and interleukin-1 (IL-1), activating downstream NF-κB and MAP kinase signaling pathways essential for inflammation, immune responses, cell survival, and apoptosis. Dysregulation of Tak1 function is associated with various pathological conditions, including cancer and inflammatory diseases, making Tak1 a critical target for biomedical research. Tak1 monoclonal antibody (C-9) enables the study of key signaling pathways and their roles in disease mechanisms. Tak1 monoclonal antibody (C-9) is available in non-conjugated form and multiple conjugated forms, including agarose, HRP, PE, FITC, and several Alexa Fluor® conjugates, facilitating versatile applications in research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Tak1 Antibody (C-9) References:

1. Protein kinase cascades in meiotic and mitotic cell cycle control.  |  Pelech, SL., et al. 1990. Biochem Cell Biol. 68: 1297-330. PMID: 2085430
2. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.  |  Morrison, DK., et al. 1988. Proc Natl Acad Sci U S A. 85: 8855-9. PMID: 3057494
3. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.  |  Ray, LB. and Sturgill, TW. 1988. Proc Natl Acad Sci U S A. 85: 3753-7. PMID: 3287375
4. TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage.  |  Xu, P., et al. 2021. J Neuroinflammation. 18: 188. PMID: 34461942
5. Characterization of murine A-raf, a new oncogene related to the v-raf oncogene.  |  Huleihel, M., et al. 1986. Mol Cell Biol. 6: 2655-62. PMID: 3491291
6. The Role of TAK1 in RANKL-Induced Osteoclastogenesis.  |  Jianwei, W., et al. 2022. Calcif Tissue Int. 111: 1-12. PMID: 35286417
7. TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.  |  Su, W., et al. 2023. JHEP Rep. 5: 100695. PMID: 36968217
8. TAK1 is an essential kinase for STING trafficking.  |  Ma, M., et al. 2023. Mol Cell. 83: 3885-3903.e5. PMID: 37832545
9. KSR: a novel player in the RAS pathway.  |  Downward, J. 1995. Cell. 83: 831-4. PMID: 8521506
10. KSR, a novel protein kinase required for RAS signal transduction.  |  Therrien, M., et al. 1995. Cell. 83: 879-88. PMID: 8521512
11. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.  |  Sundaram, M. and Han, M. 1995. Cell. 83: 889-901. PMID: 8521513
12. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.  |  Yamaguchi, K., et al. 1995. Science. 270: 2008-11. PMID: 8533096

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tak1 Antibody (C-9) has 66 citations in a variety of scientific publications.

Primary antibodies like Anti-Tak1 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tak1 Antibody (C-9) Specifications

Alternate Product Name: Tak1

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-579

Epitope Target: Tak1

Epitope Species: mouse

Product Reactivity/Detection: Tak1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 66 citations in various scientific publications

Available Conjugates/Forms for Tak1 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Tak1 antibody is Tak1 Antibody (H-5): sc-166562.