Tak1 Antibody (H-5): sc-166562

Tak1 Antibody (H-5) is a mouse monoclonal IgG3 antibody raised against a peptide mapping at the C-terminus of Tak1 (Transforming Growth Factor-beta Activated Kinase 1) of mouse origin, also known as MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7). Tak1 (clone H-5) antibody detects Tak1 protein from mouse, rat, human, equine, bovine, and porcine sources by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Tak1 is a critical serine/threonine kinase located primarily in the cytoplasm, where Tak1 plays a pivotal role in signal transduction pathways by mediating cellular responses to cytokines such as TGFβ (Transforming Growth Factor-beta) and interleukin-1 (IL-1). The cytoplasmic localization of Tak1 is essential for interacting with upstream activators and downstream effectors, influencing processes like inflammation, immune responses, cell survival, and apoptosis. Dysregulation of Tak1 function has been linked to various pathological conditions, including cancer and inflammatory diseases, making Tak1 an important target for biomedical research. Anti-Tak1 antibody (H-5) facilitates the study of key signaling pathways and their roles in disease mechanisms.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tak1 Antibody (H-5) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-Tak1 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tak1 Antibody (H-5) Specifications

Alternate Product Name: Tak1

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids: 563-579

Epitope Target: Tak1

Epitope Species: mouse

Product Reactivity/Detection: Tak1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for Tak1 Antibody (H-5): P: Blocking Peptide

The preferred Tak1 antibody is Tak1 Antibody (C-9): sc-7967.