TADA2B Antibody (MB-56): sc-130479

TADA2B Antibody (MB-56) is a mouse monoclonal IgG2a kappa light chain antibody that detects TADA2B protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TADA2B antibody (MB-56) is available as a non-conjugated format. TADA2B, also known as Transcriptional adapter 2-beta or ADA2B, is a crucial 420 amino acid protein localized in the nucleus, where TADA2B plays a significant role in transcriptional regulation. TADA2B contains one SANT domain, which facilitates protein-protein interactions, and one ZZ-type zinc finger, a motif essential for protein-DNA binding. TADA2B acts as an activator for Pax-5-dependent transcription, a process vital for B-cell development and function. TADA2B achieves this by interacting with key proteins such as Brg-1 and BAF57, which are integral to the formation of the histone acetyltransferase complex, thereby linking transcriptional activators to the basal transcription machinery. TADA2B exists in three isoforms due to alternative splicing, which may contribute to functional diversity in various cellular contexts.

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TADA2B Antibody (MB-56) References:

1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription.  |  Barlev, NA., et al. 2003. Mol Cell Biol. 23: 6944-57. PMID: 12972612
2. The SANT domain: a unique histone-tail-binding module?  |  Boyer, LA., et al. 2004. Nat Rev Mol Cell Biol. 5: 158-63. PMID: 15040448
3. Drosophila Ada2b is required for viability and normal histone H3 acetylation.  |  Qi, D., et al. 2004. Mol Cell Biol. 24: 8080-9. PMID: 15340070
4. The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions.  |  Pankotai, T., et al. 2005. Mol Cell Biol. 25: 8215-27. PMID: 16135810
5. Genome-scale CRISPR-Cas9 knockout screening in human cells.  |  Shalem, O., et al. 2014. Science. 343: 84-87. PMID: 24336571
6. Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex.  |  Nguyen-Huynh, NT., et al. 2015. Protein Sci. 24: 1232-46. PMID: 25753033
7. Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes.  |  Caliskan, G., et al. 2017. PLoS One. 12: e0189193. PMID: 29232376
8. Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.  |  Naxerova, K., et al. 2021. Genes Dev. 35: 1527-1547. PMID: 34711655
9. Integrative analysis of histone acetyltransferase KAT2A in human cancer.  |  Li, H., et al. 2023. Cancer Biomark. 38: 443-463. PMID: 38007639
10. Divergent transcriptomic profiles in depressed individuals with hyper- and hypophagia implicating inflammatory status.  |  Dan, S., et al. 2024. J Psychiatr Res. 179: 209-219. PMID: 39316935
11. ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins.  |  Ponting, CP., et al. 1996. Trends Biochem Sci. 21: 11-13. PMID: 8848831
12. The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB.  |  Aasland, R., et al. 1996. Trends Biochem Sci. 21: 87-8. PMID: 8882580

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TADA2B Antibody (MB-56) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TADA2B Antibody (MB-56) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TADA2B Antibody (MB-56) Specifications

Alternate Product Name: TADA2B

Product Clone Name: MB-56

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 2-111

Epitope Target: TADA2B

Epitope Species: human

Product Reactivity/Detection: TADA2B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TADA2B Antibody (MB-56): N/A